Your browser doesn't support javascript.
loading
Synthesis and in vitro investigation of potential antiproliferative monosaccharide-d-secoestrone bioconjugates.
Bodnár, Brigitta; Mernyák, Erzsébet; Szabó, Johanna; Wölfling, János; Schneider, Gyula; Zupkó, István; Kupihár, Zoltán; Kovács, Lajos.
Afiliação
  • Bodnár B; Department of Medicinal Chemistry, University of Szeged, Dóm tér 8, H-6720 Szeged, Hungary.
  • Mernyák E; Department of Organic Chemistry, University of Szeged, Dóm tér 8, H-6720 Szeged, Hungary.
  • Szabó J; Department of Organic Chemistry, University of Szeged, Dóm tér 8, H-6720 Szeged, Hungary.
  • Wölfling J; Department of Organic Chemistry, University of Szeged, Dóm tér 8, H-6720 Szeged, Hungary.
  • Schneider G; Department of Organic Chemistry, University of Szeged, Dóm tér 8, H-6720 Szeged, Hungary.
  • Zupkó I; Department of Pharmacodynamics and Biopharmacy, University of Szeged, Eötvös u. 6, H-6720 Szeged, Hungary.
  • Kupihár Z; Department of Medicinal Chemistry, University of Szeged, Dóm tér 8, H-6720 Szeged, Hungary. Electronic address: kupihar.zoltan@med.u-szeged.hu.
  • Kovács L; Department of Medicinal Chemistry, University of Szeged, Dóm tér 8, H-6720 Szeged, Hungary. Electronic address: kovacs.lajos@med.u-szeged.hu.
Bioorg Med Chem Lett ; 27(9): 1938-1942, 2017 05 01.
Article em En | MEDLINE | ID: mdl-28343874
ABSTRACT
The syntheses of monosaccharide-d-secoestrone conjugates are reported. They were prepared from 3-(prop-2-inyloxy)-d-secoestrone alcohol or oxime and monosaccharide azides via Cu(I)-catalyzed azide-alkyne cycloaddition reactions (CuAAC). The antiproliferative activities of the conjugates were investigated in vitro against a panel of human adherent cancer cell lines (HeLa, A2780 and MCF-7) by means of MTT assays. The protected d-glucose-containing d-secoestrone oxime bioconjugate (24b) proved to be the most effective with an IC50 value in the low micromolar range against A2780 cell line.
Assuntos
Palavras-chave
Texto completo
Imprimir
XML
PubMed Links
Buscar no Google

Texto completo: 1 Base de dados: MEDLINE Assunto principal: Glicoconjugados / Estrona / Glucose / Antineoplásicos Limite: Humans Idioma: En Ano de publicação: 2017 Tipo de documento: Article
Texto completo
Imprimir
XML
PubMed Links
Buscar no Google

Texto completo: 1 Base de dados: MEDLINE Assunto principal: Glicoconjugados / Estrona / Glucose / Antineoplásicos Limite: Humans Idioma: En Ano de publicação: 2017 Tipo de documento: Article