Macrophilone A: Structure Elucidation, Total Synthesis, and Functional Evaluation of a Biologically Active Iminoquinone from the Marine Hydroid Macrorhynchia philippina.
Org Lett
; 19(7): 1726-1729, 2017 04 07.
Article
em En
| MEDLINE
| ID: mdl-28345939
ABSTRACT
A previously uncharacterized pyrroloiminoquinone natural product, macrophilone A, was isolated from the stinging hydroid Macrorhynchia philippina. The structure was assigned utilizing long-range NMR couplings and DFT calculations and proved by a concise, five-step total synthesis. Macrophilone A and a synthetic analogue displayed potent biological activity, including increased intracellular reactive oxygen species levels and submicromolar cytotoxicity toward lung adenocarcinoma cells.
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Quinonas
Idioma:
En
Ano de publicação:
2017
Tipo de documento:
Article