Iron Efflux by PmtA Is Critical for Oxidative Stress Resistance and Contributes Significantly to Group A Streptococcus Virulence.

VanderWal, Arica R; Makthal, Nishanth; Pinochet-Barros, Azul; Helmann, John D; Olsen, Randall J; Kumaraswami, Muthiah

VanderWal, Arica R; Makthal, Nishanth; Pinochet-Barros, Azul; Helmann, John D; Olsen, Randall J; Kumaraswami, Muthiah.

Afiliação

VanderWal AR; Center for Molecular and Translational Human Infectious Diseases Research, Houston Methodist Research Institute, and Department of Pathology and Genomic Medicine, Houston Methodist Hospital, Houston, Texas, USA.
Makthal N; Center for Molecular and Translational Human Infectious Diseases Research, Houston Methodist Research Institute, and Department of Pathology and Genomic Medicine, Houston Methodist Hospital, Houston, Texas, USA.
Pinochet-Barros A; Department of Microbiology, Cornell University, Ithaca, New York, USA.
Helmann JD; Department of Microbiology, Cornell University, Ithaca, New York, USA.
Olsen RJ; Center for Molecular and Translational Human Infectious Diseases Research, Houston Methodist Research Institute, and Department of Pathology and Genomic Medicine, Houston Methodist Hospital, Houston, Texas, USA.
Kumaraswami M; Center for Molecular and Translational Human Infectious Diseases Research, Houston Methodist Research Institute, and Department of Pathology and Genomic Medicine, Houston Methodist Hospital, Houston, Texas, USA mkumaraswami@houstonmethodist.org.

Infect Immun ; 85(6)2017 06.

Article em En | MEDLINE | ID: mdl-28348051

Assuntos

Proteínas de Bactérias/metabolismo; Metiltransferases/metabolismo; Estresse Oxidativo; Proteínas Repressoras/metabolismo; Streptococcus pyogenes/patogenicidade; Animais; Proteínas de Bactérias/genética; Feminino; Regulação Bacteriana da Expressão Gênica; Peróxido de Hidrogênio/farmacologia; Metiltransferases/genética; Camundongos; RNA Bacteriano/genética; Regulon; Proteínas Repressoras/genética; Infecções Estreptocócicas/genética; Infecções Estreptocócicas/microbiologia; Streptococcus pyogenes/genética; Streptococcus pyogenes/metabolismo; Virulência

Palavras-chave

bacterial pathogenesis; gene regulation; iron efflux; metal homeostasis; oxidative stress

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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Proteínas Repressoras / Streptococcus pyogenes / Proteínas de Bactérias / Estresse Oxidativo / Metiltransferases Tipo de estudo: Prognostic_studies Limite: Animals Idioma: En Ano de publicação: 2017 Tipo de documento: Article

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