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Pulmonary exposure to metallic nanomaterials during pregnancy irreversibly impairs lung development of the offspring.
Paul, Emmanuel; Franco-Montoya, Marie-Laure; Paineau, Erwan; Angeletti, Bernard; Vibhushan, Shamila; Ridoux, Audrey; Tiendrebeogo, Arnaud; Salome, Murielle; Hesse, Bernhard; Vantelon, Delphine; Rose, Jérôme; Canouï-Poitrine, Florence; Boczkowski, Jorge; Lanone, Sophie; Delacourt, Christophe; Pairon, Jean-Claude.
Afiliação
  • Paul E; a Inserm U955, Equipe 04 , Créteil , France.
  • Franco-Montoya ML; b Faculté de Médecine, DHU A-TVB, IMRB , Université Paris Est Créteil , Créteil , France.
  • Paineau E; a Inserm U955, Equipe 04 , Créteil , France.
  • Angeletti B; b Faculté de Médecine, DHU A-TVB, IMRB , Université Paris Est Créteil , Créteil , France.
  • Vibhushan S; c Laboratoire de Physique des Solides, CNRS, University of Paris-Sud, Université Paris-Saclay , Orsay , France.
  • Ridoux A; d CEREGE, Aix Marseille Université-CNRS-IRD-Collège de France , Aix-en-Provence , France.
  • Tiendrebeogo A; a Inserm U955, Equipe 04 , Créteil , France.
  • Salome M; b Faculté de Médecine, DHU A-TVB, IMRB , Université Paris Est Créteil , Créteil , France.
  • Hesse B; a Inserm U955, Equipe 04 , Créteil , France.
  • Vantelon D; b Faculté de Médecine, DHU A-TVB, IMRB , Université Paris Est Créteil , Créteil , France.
  • Rose J; a Inserm U955, Equipe 04 , Créteil , France.
  • Canouï-Poitrine F; b Faculté de Médecine, DHU A-TVB, IMRB , Université Paris Est Créteil , Créteil , France.
  • Boczkowski J; e European Synchrotron Radiation Facility , Grenoble , France.
  • Lanone S; e European Synchrotron Radiation Facility , Grenoble , France.
  • Delacourt C; f Synchrotron SOLEIL , Gif-sur-Yvette , France.
  • Pairon JC; d CEREGE, Aix Marseille Université-CNRS-IRD-Collège de France , Aix-en-Provence , France.
Nanotoxicology ; 11(4): 484-495, 2017 May.
Article em En | MEDLINE | ID: mdl-28358292
Due to the growing commercial applications of manufactured nanoparticles (NPs), toxicological studies on NPs, especially during the critical window of development, are of major importance. The aim of the study was to assess the impact of respiratory exposure to metallic and metal oxide NPs during pregnancy on lung development of the offspring and to determine the key parameters involved in lung alterations. Pregnant mice were exposed to weekly doses of 100 µg (total dose 300 µg) of titanium dioxide (TiO2), cerium oxide (CeO2), silver (Ag) NPs or saline solution by nonsurgical intratracheal instillation. The offspring lungs were analyzed at different stages of lung development: fetal stage (gestational day 17.5), pulmonary alveolarization (post-delivery day 14.5) and lung maturity (post-delivery day 49.5). Regardless of the type of NP, maternal exposure during gestation induced long-lasting impairment of lung development of the offspring. This effect was accompanied by: i) decreased placental efficiency together with the presence of NPs in placenta, ii) no increase of inflammatory mediators present in amniotic fluid, placenta or offspring lungs and iii) decreased pulmonary expression of vascular endothelial growth factor-α (VEGF-α) and matrix metalloproteinase 9 (MMP-9) at the fetal stage, and fibroblast growth factor-18 (FGF-18) at the alveolarization stage. Respiratory exposure to metallic NPs during pregnancy induces stereotyped impairment of lung development with a lasting effect in adult mice, independently of the chemical nature of the NP.
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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Efeitos Tardios da Exposição Pré-Natal / Exposição Materna / Exposição por Inalação / Organogênese / Nanopartículas Metálicas / Pulmão Limite: Animals / Pregnancy Idioma: En Ano de publicação: 2017 Tipo de documento: Article

Texto completo: 1 Base de dados: MEDLINE Assunto principal: Efeitos Tardios da Exposição Pré-Natal / Exposição Materna / Exposição por Inalação / Organogênese / Nanopartículas Metálicas / Pulmão Limite: Animals / Pregnancy Idioma: En Ano de publicação: 2017 Tipo de documento: Article