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Detailed Characterization of the In Vitro Pharmacological and Pharmacokinetic Properties of N-(2-Hydroxybenzyl)-2,5-Dimethoxy-4-Cyanophenylethylamine (25CN-NBOH), a Highly Selective and Brain-Penetrant 5-HT2A Receptor Agonist.
Jensen, Anders A; McCorvy, John D; Leth-Petersen, Sebastian; Bundgaard, Christoffer; Liebscher, Gudrun; Kenakin, Terry P; Bräuner-Osborne, Hans; Kehler, Jan; Kristensen, Jesper Langgaard.
Afiliação
  • Jensen AA; Department of Drug Design and Pharmacology, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark (A.A.J., S.L-P., G.L., H.B.-O., J.L.K.); Department of Pharmacology, University of North Carolina School of Medicine, Chapel Hill, North Carolina (J.D.M., T.P.K.); and De
  • McCorvy JD; Department of Drug Design and Pharmacology, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark (A.A.J., S.L-P., G.L., H.B.-O., J.L.K.); Department of Pharmacology, University of North Carolina School of Medicine, Chapel Hill, North Carolina (J.D.M., T.P.K.); and De
  • Leth-Petersen S; Department of Drug Design and Pharmacology, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark (A.A.J., S.L-P., G.L., H.B.-O., J.L.K.); Department of Pharmacology, University of North Carolina School of Medicine, Chapel Hill, North Carolina (J.D.M., T.P.K.); and De
  • Bundgaard C; Department of Drug Design and Pharmacology, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark (A.A.J., S.L-P., G.L., H.B.-O., J.L.K.); Department of Pharmacology, University of North Carolina School of Medicine, Chapel Hill, North Carolina (J.D.M., T.P.K.); and De
  • Liebscher G; Department of Drug Design and Pharmacology, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark (A.A.J., S.L-P., G.L., H.B.-O., J.L.K.); Department of Pharmacology, University of North Carolina School of Medicine, Chapel Hill, North Carolina (J.D.M., T.P.K.); and De
  • Kenakin TP; Department of Drug Design and Pharmacology, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark (A.A.J., S.L-P., G.L., H.B.-O., J.L.K.); Department of Pharmacology, University of North Carolina School of Medicine, Chapel Hill, North Carolina (J.D.M., T.P.K.); and De
  • Bräuner-Osborne H; Department of Drug Design and Pharmacology, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark (A.A.J., S.L-P., G.L., H.B.-O., J.L.K.); Department of Pharmacology, University of North Carolina School of Medicine, Chapel Hill, North Carolina (J.D.M., T.P.K.); and De
  • Kehler J; Department of Drug Design and Pharmacology, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark (A.A.J., S.L-P., G.L., H.B.-O., J.L.K.); Department of Pharmacology, University of North Carolina School of Medicine, Chapel Hill, North Carolina (J.D.M., T.P.K.); and De
  • Kristensen JL; Department of Drug Design and Pharmacology, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark (A.A.J., S.L-P., G.L., H.B.-O., J.L.K.); Department of Pharmacology, University of North Carolina School of Medicine, Chapel Hill, North Carolina (J.D.M., T.P.K.); and De
J Pharmacol Exp Ther ; 361(3): 441-453, 2017 06.
Article em En | MEDLINE | ID: mdl-28360333

Texto completo: 1 Base de dados: MEDLINE Assunto principal: Encéfalo / Barreira Hematoencefálica / Receptor 5-HT2A de Serotonina / Agonistas do Receptor 5-HT2 de Serotonina Limite: Animals / Humans / Male Idioma: En Ano de publicação: 2017 Tipo de documento: Article

Texto completo: 1 Base de dados: MEDLINE Assunto principal: Encéfalo / Barreira Hematoencefálica / Receptor 5-HT2A de Serotonina / Agonistas do Receptor 5-HT2 de Serotonina Limite: Animals / Humans / Male Idioma: En Ano de publicação: 2017 Tipo de documento: Article