Molecular Hybridization Tools in the Development of Furoxan-Based NO-Donor Prodrugs.
ChemMedChem
; 12(9): 622-638, 2017 05 09.
Article
em En
| MEDLINE
| ID: mdl-28371340
ABSTRACT
The molecular hybridization of different compounds with known pharmacological activity is a particularly prominent approach for the design of potential drugs with improved pharmacokinetic profiles. Much attention over the last decade has been focused on the synthesis of hybrid structures with a nitric oxide (NO)-donor framework, as NO is a ubiquitous and crucial regulator of cellular metabolism, affecting various physiological and pathophysiological processes. 1,2,5-Oxadiazole 2-oxides (furoxans), which are capable of exogenous NO release in the presence of thiol cofactors, are an important class of prospective NO donors. As such, a wide range of hybrid compounds that combine a furoxan ring with various pharmacologically active structures have been created. This review focuses on recent results in the synthesis and pharmacological activity of furoxan-based hybrids. Special attention is given to chemo- and regioselective methods used in the preparation of these hybrid structures, and the role of synergistic effects on their pharmacological activity, associated with the furoxan fragment.
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Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Oxidiazóis
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Pró-Fármacos
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Doadores de Óxido Nítrico
Idioma:
En
Ano de publicação:
2017
Tipo de documento:
Article