Siglec-7 restores ß-cell function and survival and reduces inflammation in pancreatic islets from patients with diabetes.

Dharmadhikari, Gitanjali; Stolz, Katharina; Hauke, Michael; Morgan, Noel G; Varki, Ajit; de Koning, Eelco; Kelm, Sørge; Maedler, Kathrin

Dharmadhikari, Gitanjali; Stolz, Katharina; Hauke, Michael; Morgan, Noel G; Varki, Ajit; de Koning, Eelco; Kelm, Sørge; Maedler, Kathrin.

Afiliação

Dharmadhikari G; Centre for Biomolecular Interactions Bremen, University of Bremen, Germany.
Stolz K; Hubrecht Institute-KNAW (Royal Netherlands Academy of Arts and Sciences) and University Medical Center Utrecht, Cancer Genomics Netherlands, Utrecht, The Netherlands.
Hauke M; Centre for Biomolecular Interactions Bremen, University of Bremen, Germany.
Morgan NG; Centre for Biomolecular Interactions Bremen, University of Bremen, Germany.
Varki A; Institute of Biomedical and Clinical Sciences, University of Exeter Medical School, RILD Building, Barrack Road, Exeter EX2 5DW, UK.
de Koning E; Glycobiology Research and Training Center and Departments of Medicine and Cellular and Molecular Medicine, University of California at San Diego, La Jolla, CA, USA.
Kelm S; Hubrecht Institute-KNAW (Royal Netherlands Academy of Arts and Sciences) and University Medical Center Utrecht, Cancer Genomics Netherlands, Utrecht, The Netherlands.
Maedler K; Leiden University Medical Center, Department of Medicine, Section of Nephrology and Section of Endocrinology, Leiden, the Netherlands.

Sci Rep ; 7: 45319, 2017 04 05.

Article em En | MEDLINE | ID: mdl-28378743

Assuntos

Antígenos de Diferenciação Mielomonocítica/metabolismo; Diabetes Mellitus Tipo 1/metabolismo; Diabetes Mellitus Tipo 2/metabolismo; Células Secretoras de Insulina/citologia; Lectinas/metabolismo; Monócitos/citologia; Animais; Antígenos de Diferenciação Mielomonocítica/genética; Movimento Celular; Sobrevivência Celular; Células Cultivadas; Citocinas/metabolismo; Diabetes Mellitus Tipo 1/genética; Diabetes Mellitus Tipo 2/genética; Regulação para Baixo; Humanos; Células Secretoras de Insulina/metabolismo; Lectinas/genética; Camundongos; Monócitos/metabolismo; Especificidade de Órgãos

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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Monócitos / Antígenos de Diferenciação Mielomonocítica / Diabetes Mellitus Tipo 1 / Diabetes Mellitus Tipo 2 / Células Secretoras de Insulina / Lectinas Limite: Animals / Humans Idioma: En Ano de publicação: 2017 Tipo de documento: Article

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