Design, synthesis, and structure-activity relationship study of halogen containing 2-benzylidene-1-indanone derivatives for inhibition of LPS-stimulated ROS production in RAW 264.7 macrophages.

Shrestha, Aarajana; Jin Oh, Hye; Kim, Mi Jin; Pun, Nirmala Tilija; Magar, Til Bahadur Thapa; Bist, Ganesh; Choi, Hongseok; Park, Pil-Hoon; Lee, Eung-Seok

Shrestha, Aarajana; Jin Oh, Hye; Kim, Mi Jin; Pun, Nirmala Tilija; Magar, Til Bahadur Thapa; Bist, Ganesh; Choi, Hongseok; Park, Pil-Hoon; Lee, Eung-Seok.

Afiliação

Shrestha A; College of Pharmacy, Yeungnam University, Gyeongsan 712-749, Republic of Korea.
Jin Oh H; College of Pharmacy, Yeungnam University, Gyeongsan 712-749, Republic of Korea.
Kim MJ; College of Pharmacy, Yeungnam University, Gyeongsan 712-749, Republic of Korea.
Pun NT; College of Pharmacy, Yeungnam University, Gyeongsan 712-749, Republic of Korea.
Magar TBT; College of Pharmacy, Yeungnam University, Gyeongsan 712-749, Republic of Korea.
Bist G; College of Pharmacy, Yeungnam University, Gyeongsan 712-749, Republic of Korea.
Choi H; College of Pharmacy, Yeungnam University, Gyeongsan 712-749, Republic of Korea.
Park PH; College of Pharmacy, Yeungnam University, Gyeongsan 712-749, Republic of Korea. Electronic address: parkp@yu.ac.kr.
Lee ES; College of Pharmacy, Yeungnam University, Gyeongsan 712-749, Republic of Korea. Electronic address: eslee@yu.ac.kr.

Eur J Med Chem ; 133: 121-138, 2017 Jun 16.

Article em En | MEDLINE | ID: mdl-28384544

Assuntos

Anti-Inflamatórios/química; Anti-Inflamatórios/farmacologia; Indanos/química; Indanos/farmacologia; Lipopolissacarídeos/imunologia; Macrófagos/efeitos dos fármacos; Espécies Reativas de Oxigênio/imunologia; Animais; Compostos de Benzilideno/química; Compostos de Benzilideno/farmacologia; Desenho de Fármacos; Halogenação; Macrófagos/imunologia; Camundongos; Células RAW 264.7; Relação Estrutura-Atividade

Palavras-chave

Anti-inflammatory agents; Halogen containing 2-benzylidene-1-indanone; Inhibition of ROS production; RAW 264.7 macrophages; Structure-activity relationship

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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Lipopolissacarídeos / Espécies Reativas de Oxigênio / Indanos / Macrófagos / Anti-Inflamatórios Tipo de estudo: Prognostic_studies Limite: Animals Idioma: En Ano de publicação: 2017 Tipo de documento: Article

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