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Deregulation of the non-coding genome in leukemia.
Teppo, Susanna; Heinäniemi, Merja; Lohi, Olli.
Afiliação
  • Teppo S; a Tampere Center for Child Health Research, Faculty of Medicine and Life Sciences , University of Tampere and Tampere University Hospital , Tampere , Finland.
  • Heinäniemi M; b Institute of Biomedicine, School of Medicine , University of Eastern Finland , Kuopio , Finland.
  • Lohi O; a Tampere Center for Child Health Research, Faculty of Medicine and Life Sciences , University of Tampere and Tampere University Hospital , Tampere , Finland.
RNA Biol ; 14(7): 827-830, 2017 07 03.
Article em En | MEDLINE | ID: mdl-28387584
ABSTRACT
Methodological advances that allow deeper characterization of non-coding elements in the genome have started to reveal the full spectrum of deregulation in cancer. We generated an inducible cell model to track transcriptional changes after induction of a well-known leukemia-inducing fusion gene, ETV6-RUNX1. Our data revealed widespread transcriptional alterations outside coding elements in the genome. This adds to the growing list of various alterations in the non-coding genome in cancer and pinpoints their role in diseased cellular state.
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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Leucemia / Regulação Leucêmica da Expressão Gênica / Genoma / RNA não Traduzido Limite: Humans Idioma: En Ano de publicação: 2017 Tipo de documento: Article
Texto completo
Imprimir
XML
PubMed Links
Buscar no Google

Texto completo: 1 Base de dados: MEDLINE Assunto principal: Leucemia / Regulação Leucêmica da Expressão Gênica / Genoma / RNA não Traduzido Limite: Humans Idioma: En Ano de publicação: 2017 Tipo de documento: Article