[Chronic pancreatitis: Retrospective review of 121 cases]. / ¿Es la pancreatitis crónica una enfermedad rara en Chile?: ¿Subdiagnóstico, baja prevalencia o ambos?
Rev Med Chil
; 144(12): 1544-1552, 2016 Dec.
Article
em Es
| MEDLINE
| ID: mdl-28393988
ABSTRACT
BACKGROUND:
Chronic pancreatitis (CP) is a rare disease in Chile, without a clear explanation for this low prevalence.AIM:
To analyze the characteristics of our patients with pancreatitis. MATERIAL ANDMETHODS:
Retrospective analysis of a database of patients with pancreatitis of a clinical hospital. Morphological proof of diagnosis (calcifications/calculi, alterations of ducts, local complication or histology) was obtained for every patient. History of acute pancreatitis was recorded and exocrine-endocrine function was assessed.RESULTS:
We retrieved information of 121 patients with pancreatitis (86 males) in a period of 20 years. The number of cases increased markedly every five years. The calculated incidence and prevalence was 0.8/100,000/year and 6/100,000, respectively. Pancreatic calcifications were initially observed in 93 patients and became evident during the follow-up in another six patients. Severe pain or local complications occurred in 27 patients, requiring surgery in 10 or endoscopic treatment in 15. During the years of follow-up, 55 patients were free of symptoms. Exocrine and endocrine insufficiency was demonstrated and treated in 81 and 67 patients, respectively. Alcoholic etiology was evident in 40% of patients. In 29% no etiology was identified. Mapuche origin was exceptional.CONCLUSIONS:
Late diagnosis of CP is common, since most of our patients presented with advanced stages. Even though CP is increasingly diagnosed in our hospitals, the number of cases is still far fewer when compared to other countries. Underdiagnosis alone cannot explain this difference and genetic factors might be of importance.
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Pancreatite Crônica
Tipo de estudo:
Diagnostic_studies
/
Etiology_studies
/
Incidence_studies
/
Observational_studies
/
Prevalence_studies
/
Prognostic_studies
/
Risk_factors_studies
/
Screening_studies
Limite:
Adult
/
Female
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Humans
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Male
País como assunto:
America do sul
/
Chile
Idioma:
Es
Ano de publicação:
2016
Tipo de documento:
Article