Your browser doesn't support javascript.
loading
A quorum sensing-independent path to stumpy development in Trypanosoma brucei.
Zimmermann, Henriette; Subota, Ines; Batram, Christopher; Kramer, Susanne; Janzen, Christian J; Jones, Nicola G; Engstler, Markus.
Afiliação
  • Zimmermann H; Department of Cell and Developmental Biology, Biocenter, University of Würzburg, Würzburg, Germany.
  • Subota I; Department of Cell and Developmental Biology, Biocenter, University of Würzburg, Würzburg, Germany.
  • Batram C; Department of Cell and Developmental Biology, Biocenter, University of Würzburg, Würzburg, Germany.
  • Kramer S; Department of Cell and Developmental Biology, Biocenter, University of Würzburg, Würzburg, Germany.
  • Janzen CJ; Department of Cell and Developmental Biology, Biocenter, University of Würzburg, Würzburg, Germany.
  • Jones NG; Department of Cell and Developmental Biology, Biocenter, University of Würzburg, Würzburg, Germany.
  • Engstler M; Department of Cell and Developmental Biology, Biocenter, University of Würzburg, Würzburg, Germany.
PLoS Pathog ; 13(4): e1006324, 2017 Apr.
Article em En | MEDLINE | ID: mdl-28394929
For persistent infections of the mammalian host, African trypanosomes limit their population size by quorum sensing of the parasite-excreted stumpy induction factor (SIF), which induces development to the tsetse-infective stumpy stage. We found that besides this cell density-dependent mechanism, there exists a second path to the stumpy stage that is linked to antigenic variation, the main instrument of parasite virulence. The expression of a second variant surface glycoprotein (VSG) leads to transcriptional attenuation of the VSG expression site (ES) and immediate development to tsetse fly infective stumpy parasites. This path is independent of SIF and solely controlled by the transcriptional status of the ES. In pleomorphic trypanosomes varying degrees of ES-attenuation result in phenotypic plasticity. While full ES-attenuation causes irreversible stumpy development, milder attenuation may open a time window for rescuing an unsuccessful antigenic switch, a scenario that so far has not been considered as important for parasite survival.
Assuntos

Texto completo: 1 Base de dados: MEDLINE Assunto principal: Trypanosoma brucei brucei / Variação Antigênica / Glicoproteínas de Membrana / Glicoproteínas Variantes de Superfície de Trypanosoma / Regulação da Expressão Gênica / Percepção de Quorum Limite: Animals Idioma: En Ano de publicação: 2017 Tipo de documento: Article

Texto completo: 1 Base de dados: MEDLINE Assunto principal: Trypanosoma brucei brucei / Variação Antigênica / Glicoproteínas de Membrana / Glicoproteínas Variantes de Superfície de Trypanosoma / Regulação da Expressão Gênica / Percepção de Quorum Limite: Animals Idioma: En Ano de publicação: 2017 Tipo de documento: Article