A high-glucose diet affects Achilles tendon healing in rats.
Sci Rep
; 7(1): 780, 2017 04 10.
Article
em En
| MEDLINE
| ID: mdl-28396584
ABSTRACT
Chronic and acute tendinopathies are difficult to treat and tendon healing is generally a very slow and incomplete process and our general understanding of tendon biology and regeneration lags behind that of muscle or bone. Although still largely unexplored, several studies suggest a positive effect of nutritional interventions on tendon health and repair. With this study, we aim to reveal effects of a high-glucose diet on tendon neoformation in a non-diabetic rat model of Achilles tenotomy. After surgery animals received either a high-glucose diet or a control diet for 2 and 4 weeks, respectively. Compared to the control group, tendon repair tissue thickness and stiffness were increased in the high-glucose group after 2 weeks and gait pattern was altered after 1 and 2 weeks. Cell proliferation was up to 3-fold higher and the expression of the chondrogenic marker genes Sox9, Col2a1, Acan and Comp was significantly increased 2 and 4 weeks post-surgery. Further, a moderate increase in cartilage-like areas within the repair tissue was evident after 4 weeks of a high-glucose diet regimen. In summary, we propose that a high-glucose diet significantly affects tendon healing after injury in non-diabetic rats, potentially driving chondrogenic degeneration.
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Tendão do Calcâneo
/
Traumatismos dos Tendões
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Cicatrização
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Dieta
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Glucose
Limite:
Animals
Idioma:
En
Ano de publicação:
2017
Tipo de documento:
Article