Diffusion-weighted (DW) MRI in lung cancers: ADC test-retest repeatability.
Eur Radiol
; 27(11): 4552-4562, 2017 Nov.
Article
em En
| MEDLINE
| ID: mdl-28396997
ABSTRACT
PURPOSE:
To determine the test-retest repeatability of Apparent Diffusion Coefficient (ADC) measurements across institutions and MRI vendors, plus investigate the effect of post-processing methodology on measurement precision.METHODS:
Thirty malignant lung lesions >2 cm in size (23 patients) were scanned on two occasions, using echo-planar-Diffusion-Weighted (DW)-MRI to derive whole-tumour ADC (b = 100, 500 and 800smm-2). Scanning was performed at 4 institutions (3 MRI vendors). Whole-tumour volumes-of-interest were copied from first visit onto second visit images and from one post-processing platform to an open-source platform, to assess ADC repeatability and cross-platform reproducibility.RESULTS:
Whole-tumour ADC values ranged from 0.66-1.94x10-3mm2s-1 (mean = 1.14). Within-patient coefficient-of-variation (wCV) was 7.1% (95% CI 5.7-9.6%), limits-of-agreement (LoA) -18.0 to 21.9%. Lesions >3 cm had improved repeatability wCV 3.9% (95% CI 2.9-5.9%); and LoA -10.2 to 11.4%. Variability for lesions <3 cm was 2.46 times higher. ADC reproducibility across different post-processing platforms was excellent Pearson's R2 = 0.99; CoV 2.8% (95% CI 2.3-3.4%); and LoA -7.4 to 8.0%.CONCLUSION:
A free-breathing DW-MRI protocol for imaging malignant lung tumours achieved satisfactory within-patient repeatability and was robust to changes in post-processing software, justifying its use in multi-centre trials. For response evaluation in individual patients, a change in ADC >21.9% will reflect treatment-related change. KEY POINTS ⢠In lung cancer, free-breathing DWI-MRI produces acceptable images with evaluable ADC measurement. ⢠ADC repeatability coefficient-of-variation is 7.1% for lung tumours >2 cm. ⢠ADC repeatability coefficient-of-variation is 3.9% for lung tumours >3 cm. ⢠ADC measurement precision is unaffected by the post-processing software used. ⢠In multicentre trials, 22% increase in ADC indicates positive treatment response.Palavras-chave
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Base de dados:
MEDLINE
Assunto principal:
Imagem de Difusão por Ressonância Magnética
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Neoplasias Pulmonares
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Estadiamento de Neoplasias
Tipo de estudo:
Clinical_trials
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Diagnostic_studies
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Guideline
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Observational_studies
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Prognostic_studies
Limite:
Adult
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Aged
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Aged80
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Female
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Humans
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Male
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Middle aged
Idioma:
En
Ano de publicação:
2017
Tipo de documento:
Article