Heart rate recovery improvement in patients following acute myocardial infarction: exercise training, ß-blocker therapy or both.
Clin Physiol Funct Imaging
; 38(3): 351-359, 2018 May.
Article
em En
| MEDLINE
| ID: mdl-28402023
ABSTRACT
Heart rate recovery (HRR) is a strong mortality predictor. Exercise training (ET) and ß-blocker therapy have significant impact on the HRR of patients following myocardial infarction (MI). However, the combination of ET and ß-blocker therapy, as well as its effectiveness in patients with a more compromised HRR (≤12 bpm), has been under-studied. Male patients (n = 64) post-MI were divided Training + ß-blocker (n = 19), Training (n = 15), ß-blocker (n = 11) and Control (n = 19). Participants performed an ergometric test before and after 3 months of intervention. HRR was obtained during 5 min of recovery and corrected by the cardiac reserve (HRRcorrCR ). Compared to pre-intervention, HRRcorrCR was significantly increased during the 1st and 2nd minutes of recovery in the Training + ß-blocker group (70·5% and 37·5%, respectively; P<0·05). A significant improvement, lasting from the 1st to the 4th minute of recovery, was also observed in the Training group (47%, 50%, 25% and 8·7%, respectively; P<0·05). In contrast, the ß-blocker group showed a reduction in HRRcorrCR during the 2nd and 3rd minutes of recovery (-21·2% and -16·3%, respectively; P<0·05). In addition, interventions involving ET (Training + ßb, Training) were significantly more effective in patients with a pre-intervention HRR ≤ 12 bpm than for patients with HRR > 12 bpm. Combination of ß-blocker therapy with ET does not compromise the effect of training and instead promotes HRR and aerobic capacity improvement. In addition, this combination is particularly beneficial for individuals presenting with a more compromised HRR. However, chronic administration of ß-blocker therapy alone did not promote improvement in HRR or aerobic capacity.
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Base de dados:
MEDLINE
Assunto principal:
Tolerância ao Exercício
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Antagonistas Adrenérgicos beta
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Terapia por Exercício
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Infarto do Miocárdio com Supradesnível do Segmento ST
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Reabilitação Cardíaca
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Frequência Cardíaca
Tipo de estudo:
Diagnostic_studies
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Prognostic_studies
Limite:
Humans
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Male
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Middle aged
Idioma:
En
Ano de publicação:
2018
Tipo de documento:
Article