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Benzoisoquinolinediones as Potent and Selective Inhibitors of BRPF2 and TAF1/TAF1L Bromodomains.
Bouché, Léa; Christ, Clara D; Siegel, Stephan; Fernández-Montalván, Amaury E; Holton, Simon J; Fedorov, Oleg; Ter Laak, Antonius; Sugawara, Tatsuo; Stöckigt, Detlef; Tallant, Cynthia; Bennett, James; Monteiro, Octovia; Díaz-Sáez, Laura; Siejka, Paulina; Meier, Julia; Pütter, Vera; Weiske, Jörg; Müller, Susanne; Huber, Kilian V M; Hartung, Ingo V; Haendler, Bernard.
Afiliação
  • Bouché L; Drug Discovery, Bayer AG , Müllerstrasse 178, 13353 Berlin, Germany.
  • Christ CD; Drug Discovery, Bayer AG , Müllerstrasse 178, 13353 Berlin, Germany.
  • Siegel S; Drug Discovery, Bayer AG , Müllerstrasse 178, 13353 Berlin, Germany.
  • Fernández-Montalván AE; Drug Discovery, Bayer AG , Müllerstrasse 178, 13353 Berlin, Germany.
  • Holton SJ; Drug Discovery, Bayer AG , Müllerstrasse 178, 13353 Berlin, Germany.
  • Fedorov O; Structural Genomics Consortium, Nuffield Department of Clinical Medicine, University of Oxford , Roosevelt Drive, Oxford OX3 7DQ, U.K.
  • Ter Laak A; Target Discovery Institute, Nuffield Department of Clinical Medicine, University of Oxford , Roosevelt Drive, Oxford OX3 7FZ, U.K.
  • Sugawara T; Drug Discovery, Bayer AG , Müllerstrasse 178, 13353 Berlin, Germany.
  • Stöckigt D; Drug Discovery, Bayer AG , Müllerstrasse 178, 13353 Berlin, Germany.
  • Tallant C; Drug Discovery, Bayer AG , Müllerstrasse 178, 13353 Berlin, Germany.
  • Bennett J; Structural Genomics Consortium, Nuffield Department of Clinical Medicine, University of Oxford , Roosevelt Drive, Oxford OX3 7DQ, U.K.
  • Monteiro O; Target Discovery Institute, Nuffield Department of Clinical Medicine, University of Oxford , Roosevelt Drive, Oxford OX3 7FZ, U.K.
  • Díaz-Sáez L; Structural Genomics Consortium, Nuffield Department of Clinical Medicine, University of Oxford , Roosevelt Drive, Oxford OX3 7DQ, U.K.
  • Siejka P; Target Discovery Institute, Nuffield Department of Clinical Medicine, University of Oxford , Roosevelt Drive, Oxford OX3 7FZ, U.K.
  • Meier J; Structural Genomics Consortium, Nuffield Department of Clinical Medicine, University of Oxford , Roosevelt Drive, Oxford OX3 7DQ, U.K.
  • Pütter V; Target Discovery Institute, Nuffield Department of Clinical Medicine, University of Oxford , Roosevelt Drive, Oxford OX3 7FZ, U.K.
  • Weiske J; Structural Genomics Consortium, Nuffield Department of Clinical Medicine, University of Oxford , Roosevelt Drive, Oxford OX3 7DQ, U.K.
  • Müller S; Target Discovery Institute, Nuffield Department of Clinical Medicine, University of Oxford , Roosevelt Drive, Oxford OX3 7FZ, U.K.
  • Huber KVM; Structural Genomics Consortium, Nuffield Department of Clinical Medicine, University of Oxford , Roosevelt Drive, Oxford OX3 7DQ, U.K.
  • Hartung IV; Target Discovery Institute, Nuffield Department of Clinical Medicine, University of Oxford , Roosevelt Drive, Oxford OX3 7FZ, U.K.
  • Haendler B; Structural Genomics Consortium, Nuffield Department of Clinical Medicine, University of Oxford , Roosevelt Drive, Oxford OX3 7DQ, U.K.
J Med Chem ; 60(9): 4002-4022, 2017 05 11.
Article em En | MEDLINE | ID: mdl-28402630
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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Fatores de Transcrição / Proteínas Nucleares / Fatores Associados à Proteína de Ligação a TATA / Fator de Transcrição TFIID / Histona Acetiltransferases / Isoquinolinas Tipo de estudo: Prognostic_studies Limite: Animals / Humans Idioma: En Ano de publicação: 2017 Tipo de documento: Article
Texto completo
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XML
PubMed Links
Buscar no Google

Texto completo: 1 Base de dados: MEDLINE Assunto principal: Fatores de Transcrição / Proteínas Nucleares / Fatores Associados à Proteína de Ligação a TATA / Fator de Transcrição TFIID / Histona Acetiltransferases / Isoquinolinas Tipo de estudo: Prognostic_studies Limite: Animals / Humans Idioma: En Ano de publicação: 2017 Tipo de documento: Article