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Azithromycin Causes a Novel Proarrhythmic Syndrome.
Yang, Zhenjiang; Prinsen, Joseph K; Bersell, Kevin R; Shen, Wangzhen; Yermalitskaya, Liudmila; Sidorova, Tatiana; Luis, Paula B; Hall, Lynn; Zhang, Wei; Du, Liping; Milne, Ginger; Tucker, Patrick; George, Alfred L; Campbell, Courtney M; Pickett, Robert A; Shaffer, Christian M; Chopra, Nagesh; Yang, Tao; Knollmann, Bjorn C; Roden, Dan M; Murray, Katherine T.
Afiliação
  • Yang Z; From the Department of Medicine and Department of Pharmacology, Vanderbilt University School of Medicine, Nashville, TN.
  • Prinsen JK; From the Department of Medicine and Department of Pharmacology, Vanderbilt University School of Medicine, Nashville, TN.
  • Bersell KR; From the Department of Medicine and Department of Pharmacology, Vanderbilt University School of Medicine, Nashville, TN.
  • Shen W; From the Department of Medicine and Department of Pharmacology, Vanderbilt University School of Medicine, Nashville, TN.
  • Yermalitskaya L; From the Department of Medicine and Department of Pharmacology, Vanderbilt University School of Medicine, Nashville, TN.
  • Sidorova T; From the Department of Medicine and Department of Pharmacology, Vanderbilt University School of Medicine, Nashville, TN.
  • Luis PB; From the Department of Medicine and Department of Pharmacology, Vanderbilt University School of Medicine, Nashville, TN.
  • Hall L; From the Department of Medicine and Department of Pharmacology, Vanderbilt University School of Medicine, Nashville, TN.
  • Zhang W; From the Department of Medicine and Department of Pharmacology, Vanderbilt University School of Medicine, Nashville, TN.
  • Du L; From the Department of Medicine and Department of Pharmacology, Vanderbilt University School of Medicine, Nashville, TN.
  • Milne G; From the Department of Medicine and Department of Pharmacology, Vanderbilt University School of Medicine, Nashville, TN.
  • Tucker P; From the Department of Medicine and Department of Pharmacology, Vanderbilt University School of Medicine, Nashville, TN.
  • George AL; From the Department of Medicine and Department of Pharmacology, Vanderbilt University School of Medicine, Nashville, TN.
  • Campbell CM; From the Department of Medicine and Department of Pharmacology, Vanderbilt University School of Medicine, Nashville, TN.
  • Pickett RA; From the Department of Medicine and Department of Pharmacology, Vanderbilt University School of Medicine, Nashville, TN.
  • Shaffer CM; From the Department of Medicine and Department of Pharmacology, Vanderbilt University School of Medicine, Nashville, TN.
  • Chopra N; From the Department of Medicine and Department of Pharmacology, Vanderbilt University School of Medicine, Nashville, TN.
  • Yang T; From the Department of Medicine and Department of Pharmacology, Vanderbilt University School of Medicine, Nashville, TN.
  • Knollmann BC; From the Department of Medicine and Department of Pharmacology, Vanderbilt University School of Medicine, Nashville, TN.
  • Roden DM; From the Department of Medicine and Department of Pharmacology, Vanderbilt University School of Medicine, Nashville, TN.
  • Murray KT; From the Department of Medicine and Department of Pharmacology, Vanderbilt University School of Medicine, Nashville, TN. kathy.murray@vanderbilt.edu.
Circ Arrhythm Electrophysiol ; 10(4)2017 Apr.
Article em En | MEDLINE | ID: mdl-28408648
Assuntos
Antibacterianos/toxicidade; Arritmias Cardíacas/induzido quimicamente; Azitromicina/toxicidade; Frequência Cardíaca/efeitos dos fármacos; Miócitos Cardíacos/efeitos dos fármacos; Potenciais de Ação; Animais; Arritmias Cardíacas/metabolismo; Arritmias Cardíacas/fisiopatologia; Células CHO; Bloqueadores dos Canais de Cálcio/toxicidade; Canais de Cálcio Tipo L/efeitos dos fármacos; Canais de Cálcio Tipo L/genética; Canais de Cálcio Tipo L/metabolismo; Cricetulus; Relação Dose-Resposta a Droga; Eletrocardiografia Ambulatorial; Feminino; Células HEK293; Humanos; Canal de Potássio KCNQ1/antagonistas & inibidores; Canal de Potássio KCNQ1/genética; Canal de Potássio KCNQ1/metabolismo; Camundongos Endogâmicos C57BL; Miócitos Cardíacos/metabolismo; Canal de Sódio Disparado por Voltagem NAV1.5/efeitos dos fármacos; Canal de Sódio Disparado por Voltagem NAV1.5/genética; Canal de Sódio Disparado por Voltagem NAV1.5/metabolismo; Bloqueadores dos Canais de Potássio/toxicidade; Canais de Potássio Corretores do Fluxo de Internalização/antagonistas & inibidores; Canais de Potássio Corretores do Fluxo de Internalização/genética; Canais de Potássio Corretores do Fluxo de Internalização/metabolismo; Canais de Potássio de Abertura Dependente da Tensão da Membrana/antagonistas & inibidores; Canais de Potássio de Abertura Dependente da Tensão da Membrana/genética; Canais de Potássio de Abertura Dependente da Tensão da Membrana/metabolismo; Coelhos; Bloqueadores dos Canais de Sódio/toxicidade; Telemetria; Fatores de Tempo; Transfecção; Adulto Jovem
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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Arritmias Cardíacas / Azitromicina / Miócitos Cardíacos / Frequência Cardíaca / Antibacterianos Tipo de estudo: Etiology_studies Idioma: En Ano de publicação: 2017 Tipo de documento: Article
Texto completo
Imprimir
XML
PubMed Links
Buscar no Google

Texto completo: 1 Base de dados: MEDLINE Assunto principal: Arritmias Cardíacas / Azitromicina / Miócitos Cardíacos / Frequência Cardíaca / Antibacterianos Tipo de estudo: Etiology_studies Idioma: En Ano de publicação: 2017 Tipo de documento: Article