Evolutionary Origins of cGAS-STING Signaling.
Trends Immunol
; 38(10): 733-743, 2017 10.
Article
em En
| MEDLINE
| ID: mdl-28416447
ABSTRACT
Detection of foreign nucleic acids is an important strategy for innate immune recognition of pathogens. In vertebrates, pathogen-derived DNA is sensed in the cytosol by cGAS, which produces the cyclic dinucleotide (CDN) second messenger cGAMP to activate the signaling adaptor STING. While induction of antiviral type I interferons (IFNs) is the major outcome of STING activation in vertebrates, it has recently become clear that core components of the cGAS-STING pathway evolved more than 600 million years ago, predating the evolution of type I IFNs. Here we discuss the evolutionary origins of the cGAS-STING pathway, and consider the possibility that the ancestral functions of STING may have included activation of antibacterial immunity.
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Infecções Bacterianas
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Viroses
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Proteínas de Membrana
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Nucleotidiltransferases
Limite:
Animals
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Humans
Idioma:
En
Ano de publicação:
2017
Tipo de documento:
Article