Fatal Outcome of European Tick-borne Encephalitis after Vaccine Failure.

Sendi, Parham; Hirzel, Cédric; Pfister, Stefan; Ackermann-Gäumann, Rahel; Grandgirard, Denis; Hewer, Ekkehard; Nirkko, Arto C.

Afiliação

Sendi P; Institute for Infectious Diseases, University of Bern, Bern, Switzerland.
Hirzel C; Bern University Hospital, Department of Infectious Diseases, Bern, Switzerland.
Pfister S; Bern University Hospital, Department of Infectious Diseases, Bern, Switzerland.
Ackermann-Gäumann R; Institute for Infectious Diseases, University of Bern, Bern, Switzerland.
Grandgirard D; Spiez Laboratory, Swiss National Reference Centre for Tick-transmitted Diseases, Federal Office for Civil Protection, Spiez, Switzerland.
Hewer E; Institute for Infectious Diseases, University of Bern, Bern, Switzerland.
Nirkko AC; Institute of Pathology, University of Bern, Bern, Switzerland.

Front Neurol ; 8: 119, 2017.

Article em En | MEDLINE | ID: mdl-28421031

ABSTRACT

Tick-borne encephalitis is a viral disease affecting the central nervous system. It is endemic in Switzerland with 200-250 notified cases annually. Active immunization is effective for persons in all age groups. Vaccine failure is rare, in particular after a completed vaccination course. Here, we describe the case of 67-year-old man with a fatal outcome despite vaccination. The diagnosis was confirmed by extensive postmortem analyses. The diagnostic challenges of vaccine failure in tick-borne encephalitis and the dynamics of the immune response in vaccination breakthrough are discussed.

Palavras-chave

flavivirus; tick-borne encephalitis; tick-borne encephalitis vaccine; vaccine efficacy; vaccine failure

Texto completo: 1 Base de dados: MEDLINE Idioma: En Ano de publicação: 2017 Tipo de documento: Article