The impact of atosiban on pregnancy outcomes in women undergoing in vitro fertilization-embryo transfer: A meta-analysis.
PLoS One
; 12(4): e0175501, 2017.
Article
em En
| MEDLINE
| ID: mdl-28422984
ABSTRACT
BACKGROUND:
Atosiban is administered to women undergoing in vitro fertilization-embryo transfer (IVF-ET) to improve pregnancy outcomes. However, the results of this treatment were controversial. We conducted this meta-analysis to investigate whether atosiban improves pregnancy outcomes in the women undergoing in vitro fertilization (IVF).METHODS:
Databases of PubMed, EMBASE, Web of Science, China BioMedicine, and Google Scholar were systematically searched. Meta-analyses were performed to investigate whether atosiban improves pregnancy outcomes in the women undergoing IVF.RESULTS:
Our results showed that atosiban was associated with higher implantation (OR = 1.63, 95% CI 1.17-2.27; P = 0.004) and clinical pregnancy (OR = 1.84, 95% CI 1.31-2.57; P < 0.001) rates. However, atosiban showed no significant association with the miscarriage, live birth, multiple pregnancy or ectopic pregnancy rates. When a further subgroup analysis was performed in the women undergoing repeated implantation failure (RIF), implantation (OR = 1.93, 95% CI 1.45-2.57; P < 0.001), clinical pregnancy (OR = 2.48, 95% CI 1.70-3.64; P <0.001) and the live birth (OR = 2.89, 95% CI 1.78-4.67; P < 0.001) rates were significantly higher in the case group. Nevertheless, no significant difference was detected in the miscarriage and multiple pregnancy rates between the case and control groups.CONCLUSION:
Atosiban may be more appropriate for women undergoing RIF and play only a limited role in improving pregnancy outcomes in the general population of women undergoing IVF. These conclusions should be verified in large and well-designed studies.
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Vasotocina
/
Fertilização in vitro
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Taxa de Gravidez
/
Transferência Embrionária
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Antagonistas de Hormônios
Tipo de estudo:
Etiology_studies
/
Observational_studies
/
Risk_factors_studies
/
Systematic_reviews
Limite:
Female
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Humans
/
Pregnancy
Idioma:
En
Ano de publicação:
2017
Tipo de documento:
Article