Effect of size and pegylation of liposomes and peptide-based synthetic lipoproteins on tumor targeting.
Nanomedicine
; 13(6): 1869-1878, 2017 Aug.
Article
em En
| MEDLINE
| ID: mdl-28434931
ABSTRACT
Synthetic high-density lipoprotein nanoparticles (sHDL) are a valuable class of nanomedicines with established animal safety profile, clinical tolerability and therapeutic efficacy for cardiovascular applications. In this study we examined how the scavenger receptor B-I-mediated (SR-BI) tumor-targeting ability of sHDL, long plasma circulation half-life, and small particle size (9.6±0.2nm) impacted sHDL accumulation in SR-BI positive colorectal carcinoma cells, 3D tumor spheroids, and in vivo xenografts. We compared tumor accumulation of sHDL with that of liposomes (LIP, 130.7±0.8nm), pegylated liposomes (PEG-LIP, 101±2nm), and pegylated sHDL (12.1±0.1nm), all prepared with the same lipid components. sHDL penetrated deep (210µm) into tumor spheroids and exhibited 12- and 3-fold higher in vivo solid tumor accumulation, compared with LIP (p<0.01) and PEG-LIP (p<0.05), respectively. These results suggest that sHDL with established human safety possess promising intrinsic tumor-targeted properties.
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Texto completo:
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Base de dados:
MEDLINE
Assunto principal:
Polietilenoglicóis
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Neoplasias Colorretais
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Sistemas de Liberação de Medicamentos
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Nanopartículas
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Lipoproteínas HDL
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Lipossomos
Limite:
Humans
Idioma:
En
Ano de publicação:
2017
Tipo de documento:
Article