Long-term oral kinetin does not protect against &#945;-synuclein-induced neurodegeneration in rodent models of Parkinson's disease.

Orr, Adam L; Rutaganira, Florentine U; de Roulet, Daniel; Huang, Eric J; Hertz, Nicholas T; Shokat, Kevan M; Nakamura, Ken

Long-term oral kinetin does not protect against α-synuclein-induced neurodegeneration in rodent models of Parkinson's disease.

Orr, Adam L; Rutaganira, Florentine U; de Roulet, Daniel; Huang, Eric J; Hertz, Nicholas T; Shokat, Kevan M; Nakamura, Ken.

Afiliação

Orr AL; Gladstone Institute of Neurological Disease, Gladstone Institutes, San Francisco, CA, USA.
Rutaganira FU; Howard Hughes Medical Institute and Department of Cellular and Molecular Pharmacology, University of California, San Francisco, San Francisco, CA, USA.
de Roulet D; Mitokinin LLC, 2 Wall Street, 4th Floor, New York, NY, USA.
Huang EJ; Department of Pathology, University of California, San Francisco, San Francisco, CA, USA.
Hertz NT; Mitokinin LLC, 2 Wall Street, 4th Floor, New York, NY, USA.
Shokat KM; Howard Hughes Medical Institute and Department of Cellular and Molecular Pharmacology, University of California, San Francisco, San Francisco, CA, USA; Mitokinin LLC, 2 Wall Street, 4th Floor, New York, NY, USA.
Nakamura K; Gladstone Institute of Neurological Disease, Gladstone Institutes, San Francisco, CA, USA; Department of Neurology, University of California, San Francisco, San Francisco, CA, USA. Electronic address: ken.nakamura@gladstone.ucsf.edu.

Neurochem Int ; 109: 106-116, 2017 Oct.

Article em En | MEDLINE | ID: mdl-28434973

Assuntos

Modelos Animais de Doenças; Cinetina/administração & dosagem; Doenças Neurodegenerativas/metabolismo; Doença de Parkinson/metabolismo; Proteínas Quinases/deficiência; alfa-Sinucleína/biossíntese; Administração Oral; Animais; Células Cultivadas; Esquema de Medicação; Humanos; Masculino; Camundongos; Camundongos Endogâmicos C57BL; Doenças Neurodegenerativas/genética; Doenças Neurodegenerativas/prevenção & controle; Doença de Parkinson/genética; Doença de Parkinson/prevenção & controle; Proteínas Quinases/genética; Ratos; Ratos Long-Evans; Ratos Sprague-Dawley; Roedores; alfa-Sinucleína/genética

Palavras-chave

AAV; Adeno-associated virus; Kinetin; Neurodegeneration; PINK1; Parkinson's disease; α-Synuclein

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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Doença de Parkinson / Proteínas Quinases / Doenças Neurodegenerativas / Modelos Animais de Doenças / Alfa-Sinucleína / Cinetina Limite: Animals / Humans / Male Idioma: En Ano de publicação: 2017 Tipo de documento: Article

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