Synthesis, structural characterization and biological activity of novel Knoevenagel condensates on DLD-1 human colon carcinoma.
Bioorg Med Chem Lett
; 27(11): 2345-2349, 2017 06 01.
Article
em En
| MEDLINE
| ID: mdl-28438541
ABSTRACT
Biologically active Knoevenagel condensates (1-14) of diarylheptanoids 1,7-bis(3-methoxy-4-hydroxyphenyl)hepta-1,7-diene-3,5-dione and 1,7-bis(3-ethoxy-4-hydroxyphenyl)hepta-1,7-diene-3,5-dione, were synthesized and structurally characterized. Compounds 1-14 exhibited cytotoxicity against colon carcinoma cells, and their antiproliferative effect was associated with a significant decrease of multidrug resistance proteins. One of the underlying mechanisms of these effects is the reduction of intracellular and extracellular SOD enzymes by compounds 1, 12 and 14, which render the tumor cells more vulnerable to oxidative stress.
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Texto completo:
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Base de dados:
MEDLINE
Assunto principal:
Neoplasias do Colo
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Diarileptanoides
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Antineoplásicos
Limite:
Humans
Idioma:
En
Ano de publicação:
2017
Tipo de documento:
Article