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Discovery of an enzyme and substrate selective inhibitor of ADAM10 using an exosite-binding glycosylated substrate.
Madoux, Franck; Dreymuller, Daniela; Pettiloud, Jean-Phillipe; Santos, Radleigh; Becker-Pauly, Christoph; Ludwig, Andreas; Fields, Gregg B; Bannister, Thomas; Spicer, Timothy P; Cudic, Mare; Scampavia, Louis D; Minond, Dmitriy.
Afiliação
  • Madoux F; Lead Identification Division, Translational Research Institute, The Scripps Research Institute, 130 Scripps Way, Jupiter, FL, 39453, United States.
  • Dreymuller D; Institute of Pharmacology and Toxicology, RWTH Aachen University, Wendlingweg 2, 52074, Aachen, Germany.
  • Pettiloud JP; Department of Chemistry and Biochemistry, Florida Atlantic University, 5353 Parkside Drive, Jupiter, FL, 39453, United States.
  • Santos R; Torrey Pines Institute for Molecular Studies, 11350 SW Village Parkway, Port Saint Lucie, FL, 34987, United States.
  • Becker-Pauly C; University of Kiel, Institute of Biochemistry, Unit for Degradomics of the Protease Web, Rudolf-Höber-Str. 1, 24118, Kiel, Germany.
  • Ludwig A; Institute of Pharmacology and Toxicology, RWTH Aachen University, Wendlingweg 2, 52074, Aachen, Germany.
  • Fields GB; Department of Chemistry and Biochemistry, Florida Atlantic University, 5353 Parkside Drive, Jupiter, FL, 39453, United States.
  • Bannister T; Department of Molecular Therapeutics, Translational Research Institute, The Scripps Research Institute, 130 Scripps Way, Jupiter, FL, 39453, United States.
  • Spicer TP; Lead Identification Division, Translational Research Institute, The Scripps Research Institute, 130 Scripps Way, Jupiter, FL, 39453, United States.
  • Cudic M; Department of Chemistry and Biochemistry, Florida Atlantic University, 5353 Parkside Drive, Jupiter, FL, 39453, United States.
  • Scampavia LD; Lead Identification Division, Translational Research Institute, The Scripps Research Institute, 130 Scripps Way, Jupiter, FL, 39453, United States.
  • Minond D; Department of Drug Discovery and Development, Harrison School of Pharmacy, 3211B Walker Building, Auburn University, Auburn, Alabama, 36849, USA. dzm0032@auburn.edu.
Sci Rep ; 6(1): 11, 2016 Dec 05.
Article em En | MEDLINE | ID: mdl-28442704
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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Proteína ADAM10 / Proteína ADAM17 Tipo de estudo: Prognostic_studies Limite: Humans Idioma: En Ano de publicação: 2016 Tipo de documento: Article
Texto completo
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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Proteína ADAM10 / Proteína ADAM17 Tipo de estudo: Prognostic_studies Limite: Humans Idioma: En Ano de publicação: 2016 Tipo de documento: Article