Surgery or stereotactic body radiotherapy for elderly stage I lung cancer? A propensity score matching analysis.
Surg Today
; 47(12): 1476-1483, 2017 Dec.
Article
em En
| MEDLINE
| ID: mdl-28447170
ABSTRACT
PURPOSE:
The aim of this study was to compare the outcomes of surgery and stereotactic body radiotherapy (SBRT) for elderly clinical stage I non-small cell lung cancer (NSCLC) patients.METHODS:
Patients ≥80 years of age with clinical stage I NSCLC between August 2008 and December 2014 were treated either surgery or SBRT. Propensity score matching was performed to reduce bias in various clinicopathological factors.RESULTS:
Surgery was performed in 57 cases and SBRT in 41 cases. In the surgery group, the operations included 34 lobectomies and 23 sublobar resections. In the SBRT group, 27 cases were given 48 Gy in 4 fractions, and 14 were given 60 Gy in 10 fractions. Similar characteristics were identified in age (82 years), gender (malefemale ratio 21), tumor size (2.2 cm), carcinoembryonic antigen (3.6 ng/ml), Charlson comorbidity index (1), Glasgow prognostic scale (0), and forced expiratory volume in 1 s (1.7 L) after matching. Before matching, the 5-year overall survival (OS) in surgery (68.3%) was significantly better than that in SBRT (47.4%, p = 0.02), and the 5-year disease-specific survival (DSS) (94.1%, 78.2%, p = 0.17) was not significantly different between the groups. The difference in the 5-year OS became non-significant between the matched pairs (57.0%, 49.1%, p = 0.56).CONCLUSIONS:
The outcomes of surgery and SBRT for elderly patients with the early stage NSCLC were roughly the same.Palavras-chave
Texto completo:
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Base de dados:
MEDLINE
Assunto principal:
Pneumonectomia
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Radiocirurgia
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Carcinoma Pulmonar de Células não Pequenas
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Pontuação de Propensão
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Neoplasias Pulmonares
Tipo de estudo:
Prognostic_studies
Limite:
Aged80
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Female
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Humans
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Male
Idioma:
En
Ano de publicação:
2017
Tipo de documento:
Article