veqtl-mapper: variance association mapping for molecular phenotypes.
Bioinformatics
; 33(17): 2772-2773, 2017 Sep 01.
Article
em En
| MEDLINE
| ID: mdl-28449110
ABSTRACT
MOTIVATION Genetic loci associated with the variance of phenotypic traits have been of recent interest as they can be signatures of genetic interactions, gene by environment interactions, parent of origin effects and canalization. We present a fast efficient tool to map loci affecting variance of gene expression and other molecular phenotypes in cis. Results:
Applied to the publicly available Geuvadis gene expression dataset, we identify 816 loci associated with variance of gene expression using an additive model, and 32 showing differences in variance between homozygous and heterozygous alleles, signatures of parent of origin effects. AVAILABILITY AND IMPLEMENTATION Documentation and links to source code and binaries for linux can be found at https//funpopgen.github.io/veqm/ . CONTACT andrew.brown@unige.ch. SUPPLEMENTARY INFORMATION Supplementary data are available at Bioinformatics online.
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Variação Genética
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Software
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Regulação da Expressão Gênica
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Biologia Computacional
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Epistasia Genética
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Interação Gene-Ambiente
Tipo de estudo:
Risk_factors_studies
Limite:
Humans
Idioma:
En
Ano de publicação:
2017
Tipo de documento:
Article