Recurrent Massive Perivillous Fibrin Deposition and Chronic Intervillositis Treated With Heparin and Intravenous Immunoglobulin: A Case Report.
J Obstet Gynaecol Can
; 39(8): 676-681, 2017 Aug.
Article
em En
| MEDLINE
| ID: mdl-28456434
ABSTRACT
BACKGROUND:
Massive perivillous fibrin deposition (MPVFD) and chronic intervillositis (CI) are related rare pathological correlates of severe intrauterine growth restriction (IUGR) and fetal loss with high recurrence rates. No standard management has been established. CASE A patient underwent termination of pregnancy at 21 weeks for severe early onset IUGR. Placental histology showed mixed CI with MPVFD. Several months later, the patient became pregnant and was managed with prednisone and aspirin (ASA) but miscarried at 16 weeks. Placental pathology showed MPVFD and focal CI. For two subsequent pregnancies, she was treated with intravenous immunoglobulin (IVIG), heparin, and ASA. Both pregnancies resulted in healthy near-term deliveries with normal placentas.CONCLUSION:
IVIG, heparin, and ASA can be an option in patients with recurrent pregnancy loss due to MPVFD and CI.Palavras-chave
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Placenta
/
Doenças Placentárias
/
Fibrina
/
Aborto Habitual
/
Imunoglobulinas Intravenosas
/
Dalteparina
/
Fatores Imunológicos
/
Anticoagulantes
Tipo de estudo:
Etiology_studies
Limite:
Adult
/
Female
/
Humans
/
Pregnancy
Idioma:
En
Ano de publicação:
2017
Tipo de documento:
Article