Your browser doesn't support javascript.
loading
Anti-neuronal anti-bodies in patients with early psychosis.
Mantere, O; Saarela, M; Kieseppä, T; Raij, T; Mäntylä, T; Lindgren, M; Rikandi, E; Stoecker, W; Teegen, B; Suvisaari, J.
Afiliação
  • Mantere O; Department of Psychiatry, McGill University, Montréal, QC, Canada; Bipolar Disorders Clinic, Douglas Mental Health University Institute, Montréal, QC, Canada. Electronic address: outi.mantere@douglas.mcgill.ca.
  • Saarela M; Clinical Neurosciences, Neurology, University of Helsinki and Helsinki University Hospital, Helsinki, Finland. Electronic address: mika.saarela@hus.fi.
  • Kieseppä T; Department of Psychiatry, Helsinki University and Helsinki University Hospital, Helsinki, Finland. Electronic address: Tuula.kieseppa@hus.fi.
  • Raij T; Department of Psychiatry, Helsinki University and Helsinki University Hospital, Helsinki, Finland; Department of Neuroscience and Biomedical Engineering, and Advanced Magnetic Imaging Center, Aalto NeuroImaging, Aalto University School of Science, Espoo, Finland. Electronic address: tuukka.raij@hus.
  • Mäntylä T; Department of Neuroscience and Biomedical Engineering, and Advanced Magnetic Imaging Center, Aalto NeuroImaging, Aalto University School of Science, Espoo, Finland; VTT Technical Research Centre of Finland Ltd., Espoo, Finland; Mental Health Unit, National Institute for Health and Welfare, Helsinki,
  • Lindgren M; Mental Health Unit, National Institute for Health and Welfare, Helsinki, Finland. Electronic address: Maija.lindgren@thl.fi.
  • Rikandi E; Department of Neuroscience and Biomedical Engineering, and Advanced Magnetic Imaging Center, Aalto NeuroImaging, Aalto University School of Science, Espoo, Finland; Mental Health Unit, National Institute for Health and Welfare, Helsinki, Finland; Department of Psychology and Logopedics, Faculty of M
  • Stoecker W; Institute for Experimental Immunology, Euroimmun AG, Seekamp 31, 23560 Lübeck, Germany. Electronic address: winfried.stoecker@euroimmun.de.
  • Teegen B; Institute for Experimental Immunology, Euroimmun AG, Seekamp 31, 23560 Lübeck, Germany. Electronic address: b.teegen@euroimmun.de.
  • Suvisaari J; Mental Health Unit, National Institute for Health and Welfare, Helsinki, Finland. Electronic address: jaana.suvisaari@thl.fi.
Schizophr Res ; 192: 404-407, 2018 02.
Article em En | MEDLINE | ID: mdl-28461116
It may be challenging to distinguish autoimmune encephalitis associated with anti-neuronal autoantibodies from primary psychiatric disorders. Here, serum was drawn from patients with a first-episode psychosis (n=70) or a clinical high-risk for psychosis (n=6) and controls (n=34). We investigated the serum prevalence of 24 anti-neuronal autoantibodies: IgG antibodies for anti-N-methyl-d-aspartate-type glutamate receptor (anti-NMDAR), glutamate and γ-aminobutyric acid alpha and beta receptors (GABA-a, GABA-b), alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid receptor (AMPA), glycine receptor (GlyR), metabotropic glutamate receptor 1 and 5 (mGluR1, mGluR5), anti-Tr/Delta/notch-like epidermal growth factor-related receptor (DNER), contactin-associated protein-like 2 (CASPR2), myelin oligodendrocyte glycoprotein (MOG), glutamic acid decarboxylase-65 (GAD65), collapsin response mediator protein 5/crossveinless-2 (CV2), aquaporin-4 (AQP4), anti-dipeptidyl-peptidase-like protein-6 (DPPX), type 1 anti-neuronal nuclear antibody (ANNA-1, Hu), Ri, Yo, IgLON5, Ma2, zinc finger protein 4 (ZIC4), Rho GTPase-activating protein 26, amphiphysin, and recoverin, as well as IgA and IgM for dopamine-2-receptor (DRD2). Anti-NMDA IgG antibodies were positive with serum titer 1:320 in one patient with a clinical high risk for psychosis. He did not receive a diagnosis of encephalitis after comprehensive neurological evaluation. All other antineuronal autoantibodies were negative and there were no additional findings with immunohistochemistry of brain issues.
Assuntos
Palavras-chave

Texto completo: 1 Base de dados: MEDLINE Assunto principal: Transtornos Psicóticos / Autoanticorpos / Receptores de Glutamato / Sintomas Prodrômicos Tipo de estudo: Observational_studies / Prognostic_studies / Risk_factors_studies Limite: Adolescent / Adult / Female / Humans / Male Idioma: En Ano de publicação: 2018 Tipo de documento: Article

Texto completo: 1 Base de dados: MEDLINE Assunto principal: Transtornos Psicóticos / Autoanticorpos / Receptores de Glutamato / Sintomas Prodrômicos Tipo de estudo: Observational_studies / Prognostic_studies / Risk_factors_studies Limite: Adolescent / Adult / Female / Humans / Male Idioma: En Ano de publicação: 2018 Tipo de documento: Article