Synthesis and preliminary biological evaluation of [<sup>11</sup>C]methyl (2-amino-5-(benzylthio)thiazolo[4,5-d]pyrimidin-7-yl)-d-leucinate for the fractalkine receptor (CX<sub>3</sub>CR1).

Gao, Mingzhang; Wang, Min; Meyer, Jill A; Peters, Jonathan S; Zarrinmayeh, Hamideh; Territo, Paul R; Hutchins, Gary D; Zheng, Qi-Huang

Synthesis and preliminary biological evaluation of [¹¹C]methyl (2-amino-5-(benzylthio)thiazolo[4,5-d]pyrimidin-7-yl)-d-leucinate for the fractalkine receptor (CX₃CR1).

Gao, Mingzhang; Wang, Min; Meyer, Jill A; Peters, Jonathan S; Zarrinmayeh, Hamideh; Territo, Paul R; Hutchins, Gary D; Zheng, Qi-Huang.

Afiliação

Gao M; Department of Radiology and Imaging Sciences, Indiana University School of Medicine, 1345 West 16th Street, Room 202, Indianapolis, IN 46202, USA.
Wang M; Department of Radiology and Imaging Sciences, Indiana University School of Medicine, 1345 West 16th Street, Room 202, Indianapolis, IN 46202, USA.
Meyer JA; Department of Radiology and Imaging Sciences, Indiana University School of Medicine, 1345 West 16th Street, Room 202, Indianapolis, IN 46202, USA.
Peters JS; Department of Radiology and Imaging Sciences, Indiana University School of Medicine, 1345 West 16th Street, Room 202, Indianapolis, IN 46202, USA.
Zarrinmayeh H; Department of Radiology and Imaging Sciences, Indiana University School of Medicine, 1345 West 16th Street, Room 202, Indianapolis, IN 46202, USA.
Territo PR; Department of Radiology and Imaging Sciences, Indiana University School of Medicine, 1345 West 16th Street, Room 202, Indianapolis, IN 46202, USA.
Hutchins GD; Department of Radiology and Imaging Sciences, Indiana University School of Medicine, 1345 West 16th Street, Room 202, Indianapolis, IN 46202, USA.
Zheng QH; Department of Radiology and Imaging Sciences, Indiana University School of Medicine, 1345 West 16th Street, Room 202, Indianapolis, IN 46202, USA. Electronic address: qzheng@iupui.edu.

Bioorg Med Chem Lett ; 27(12): 2727-2730, 2017 06 15.

Article em En | MEDLINE | ID: mdl-28462835

Assuntos

Leucina/análogos & derivados; Pirimidinas/farmacologia; Receptores de Quimiocinas/antagonistas & inibidores; Tiazóis/farmacologia; Receptor 1 de Quimiocina CX3C; Isótopos de Carbono; Relação Dose-Resposta a Droga; Humanos; Leucina/síntese química; Leucina/química; Leucina/farmacologia; Ligantes; Estrutura Molecular; Pirimidinas/síntese química; Pirimidinas/química; Receptores de Quimiocinas/metabolismo; Relação Estrutura-Atividade; Tiazóis/síntese química; Tiazóis/química

Palavras-chave

Competitive binding assay; Fractalkine receptor (CX(3)CR1); Positron emission tomography (PET); Radioligand depletion experiment; Radiosynthesis; [(11)C]Methyl (2-amino-5-(benzylthio)thiazolo[4,5-d]pyrimidin-7-yl)-d-leucinate

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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Pirimidinas / Tiazóis / Receptores de Quimiocinas / Leucina Limite: Humans Idioma: En Ano de publicação: 2017 Tipo de documento: Article

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