Multi-criteria manufacturability indices for ranking high-concentration monoclonal antibody formulations.

Yang, Yang; Velayudhan, Ajoy; Thornhill, Nina F; Farid, Suzanne S

Yang, Yang; Velayudhan, Ajoy; Thornhill, Nina F; Farid, Suzanne S.

Afiliação

Yang Y; Centre for Process Systems Engineering, Department of Chemical Engineering, Imperial College London, South Kensington Campus, London, SW7 2AZ, UK.
Velayudhan A; The Advanced Centre for Biochemical Engineering, Department of Biochemical Engineering, University College London, Torrington Place, London, WC1E 7JE, UK.
Thornhill NF; Centre for Process Systems Engineering, Department of Chemical Engineering, Imperial College London, South Kensington Campus, London, SW7 2AZ, UK.
Farid SS; The Advanced Centre for Biochemical Engineering, Department of Biochemical Engineering, University College London, Torrington Place, London, WC1E 7JE, UK.

Biotechnol Bioeng ; 114(9): 2043-2056, 2017 09.

Article em En | MEDLINE | ID: mdl-28464235

Assuntos

Anticorpos Monoclonais/química; Anticorpos Monoclonais/isolamento & purificação; Composição de Medicamentos/métodos; Composição de Medicamentos/normas; Ultrafiltração/métodos; Ultrafiltração/normas; Estabilidade de Medicamentos; Guias como Assunto; Temperatura; Viscosidade

Palavras-chave

aggregation; data mining; developability assessment; high-concentration mAb formulation; manufacturability index; viscosity

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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Ultrafiltração / Composição de Medicamentos / Anticorpos Monoclonais Tipo de estudo: Guideline / Prognostic_studies Idioma: En Ano de publicação: 2017 Tipo de documento: Article

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