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Benzoxazolinone aryl sulfonamides as potent, selective Nav1.7 inhibitors with in vivo efficacy in a preclinical pain model.
Pero, Joseph E; Rossi, Michael A; Lehman, Hannah D G F; Kelly, Michael J; Mulhearn, James J; Wolkenberg, Scott E; Cato, Matthew J; Clements, Michelle K; Daley, Christopher J; Filzen, Tracey; Finger, Eleftheria N; Gregan, Yun; Henze, Darrell A; Jovanovska, Aneta; Klein, Rebecca; Kraus, Richard L; Li, Yuxing; Liang, Annie; Majercak, John M; Panigel, Jacqueline; Urban, Mark O; Wang, Jixin; Wang, Ying-Hong; Houghton, Andrea K; Layton, Mark E.
Afiliação
  • Pero JE; Department of Medicinal Chemistry, Merck & Co., Inc., West Point, PA 19486, USA. Electronic address: joseph.e.pero@gsk.com.
  • Rossi MA; Department of Medicinal Chemistry, Merck & Co., Inc., West Point, PA 19486, USA.
  • Lehman HDGF; Department of Medicinal Chemistry, Merck & Co., Inc., West Point, PA 19486, USA.
  • Kelly MJ; Department of Medicinal Chemistry, Merck & Co., Inc., West Point, PA 19486, USA.
  • Mulhearn JJ; Department of Medicinal Chemistry, Merck & Co., Inc., West Point, PA 19486, USA.
  • Wolkenberg SE; Department of Medicinal Chemistry, Merck & Co., Inc., West Point, PA 19486, USA.
  • Cato MJ; Department of In vitro Pharmacology, Merck & Co., Inc., West Point, PA 19486, USA.
  • Clements MK; Department of Neuroscience, Merck & Co., Inc., West Point, PA 19486, USA.
  • Daley CJ; Department of In vitro Pharmacology, Merck & Co., Inc., West Point, PA 19486, USA.
  • Filzen T; Department of In vitro Pharmacology, Merck & Co., Inc., West Point, PA 19486, USA.
  • Finger EN; Department of In vitro Pharmacology, Merck & Co., Inc., West Point, PA 19486, USA.
  • Gregan Y; Department of In vitro Pharmacology, Merck & Co., Inc., West Point, PA 19486, USA.
  • Henze DA; Department of Neuroscience, Merck & Co., Inc., West Point, PA 19486, USA.
  • Jovanovska A; Department of In vitro Pharmacology, Merck & Co., Inc., West Point, PA 19486, USA.
  • Klein R; Department of Neuroscience, Merck & Co., Inc., West Point, PA 19486, USA.
  • Kraus RL; Department of In vitro Pharmacology, Merck & Co., Inc., West Point, PA 19486, USA.
  • Li Y; Department of In vitro Pharmacology, Merck & Co., Inc., West Point, PA 19486, USA.
  • Liang A; Department of In vivo Pharmacology, Merck & Co., Inc., West Point, PA 19486, USA.
  • Majercak JM; Department of In vitro Pharmacology, Merck & Co., Inc., West Point, PA 19486, USA.
  • Panigel J; Department of Neuroscience, Merck & Co., Inc., West Point, PA 19486, USA.
  • Urban MO; Department of In vivo Pharmacology, Merck & Co., Inc., West Point, PA 19486, USA.
  • Wang J; Department of Neuroscience, Merck & Co., Inc., West Point, PA 19486, USA.
  • Wang YH; Department of Drug Metabolism and Pharmacokinetics, Merck & Co., Inc., West Point, PA 19486, USA.
  • Houghton AK; Department of In vitro Pharmacology, Merck & Co., Inc., West Point, PA 19486, USA.
  • Layton ME; Department of Medicinal Chemistry, Merck & Co., Inc., West Point, PA 19486, USA.
Bioorg Med Chem Lett ; 27(12): 2683-2688, 2017 06 15.
Article em En | MEDLINE | ID: mdl-28465103
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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Dor / Sulfonamidas / Benzoxazóis / Canal de Sódio Disparado por Voltagem NAV1.7 / Analgésicos Limite: Animals / Humans Idioma: En Ano de publicação: 2017 Tipo de documento: Article
Texto completo
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XML
PubMed Links
Buscar no Google

Texto completo: 1 Base de dados: MEDLINE Assunto principal: Dor / Sulfonamidas / Benzoxazóis / Canal de Sódio Disparado por Voltagem NAV1.7 / Analgésicos Limite: Animals / Humans Idioma: En Ano de publicação: 2017 Tipo de documento: Article