Bipotent progenitors as embryonic origin of retinal stem cells.
J Cell Biol
; 216(6): 1833-1847, 2017 06 05.
Article
em En
| MEDLINE
| ID: mdl-28465291
ABSTRACT
In lower vertebrates, retinal stem cells (RSCs) capable of producing all retinal cell types are a resource for retinal tissue growth throughout life. However, the embryonic origin of RSCs remains largely elusive. Using a Zebrabow-based clonal analysis, we characterized the RSC niche in the ciliary marginal zone of zebrafish retina and illustrate that blood vessels associated with RSCs are required for the maintenance of actively proliferating RSCs. Full lineage analysis of RSC progenitors reveals lineage patterns of RSC production. Moreover, in vivo lineage analysis demonstrates that these RSC progenitors are the direct descendants of a set of bipotent progenitors in the medial epithelial layer of developing optic vesicles, suggesting the involvement of the mixed-lineage states in the RSC lineage specification.
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Base de dados:
MEDLINE
Assunto principal:
Retina
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Peixe-Zebra
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Diferenciação Celular
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Linhagem da Célula
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Células-Tronco Embrionárias
Limite:
Animals
Idioma:
En
Ano de publicação:
2017
Tipo de documento:
Article