Impaired renal function and dysbiosis of gut microbiota contribute to increased trimethylamine-N-oxide in chronic kidney disease patients.

Xu, Kai-Yu; Xia, Geng-Hong; Lu, Jun-Qi; Chen, Mu-Xuan; Zhen, Xin; Wang, Shan; You, Chao; Nie, Jing; Zhou, Hong-Wei; Yin, Jia

Xu, Kai-Yu; Xia, Geng-Hong; Lu, Jun-Qi; Chen, Mu-Xuan; Zhen, Xin; Wang, Shan; You, Chao; Nie, Jing; Zhou, Hong-Wei; Yin, Jia.

Afiliação

Xu KY; Department of Neurology, NanFang Hospital, Southern Medical University, Guangzhou, China.
Xia GH; Department of Neurology, NanFang Hospital, Southern Medical University, Guangzhou, China.
Lu JQ; Department of Environmental Health, School of Public Health, Southern Medical University, Guangzhou, China.
Chen MX; State Key Laboratory of Organ Failure Research, Division of Laboratory Medicine, ZhuJiang Hospital, Southern Medical University, Guangzhou, China.
Zhen X; State Key Laboratory of Organ Failure Research, Division of Laboratory Medicine, ZhuJiang Hospital, Southern Medical University, Guangzhou, China.
Wang S; Department of Nephrology, NanFang Hospital, Southern Medical University, Guangzhou, China.
You C; State Key Laboratory of Organ Failure Research, Division of Laboratory Medicine, ZhuJiang Hospital, Southern Medical University, Guangzhou, China.
Nie J; Department of Neurology, NanFang Hospital, Southern Medical University, Guangzhou, China.
Zhou HW; Department of Nephrology, NanFang Hospital, Southern Medical University, Guangzhou, China.
Yin J; State Key Laboratory of Organ Failure Research, Division of Laboratory Medicine, ZhuJiang Hospital, Southern Medical University, Guangzhou, China. zhou_hong_wei@qq.com.

Sci Rep ; 7(1): 1445, 2017 05 03.

Article em En | MEDLINE | ID: mdl-28469156

Assuntos

Clostridiaceae/metabolismo; Disbiose/metabolismo; Gammaproteobacteria/metabolismo; Microbioma Gastrointestinal/genética; Metilaminas/sangue; Insuficiência Renal Crônica/metabolismo; Adulto; Idoso; Animais; Betaína/metabolismo; Carnitina/metabolismo; Estudos de Casos e Controles; Colina/metabolismo; Clostridiaceae/classificação; Clostridiaceae/genética; Disbiose/microbiologia; Disbiose/patologia; Transplante de Microbiota Fecal; Feminino; Gammaproteobacteria/classificação; Gammaproteobacteria/genética; Sequenciamento de Nucleotídeos em Larga Escala; Humanos; Testes de Função Renal; Masculino; Camundongos; Camundongos Endogâmicos C57BL; Pessoa de Meia-Idade; Insuficiência Renal Crônica/microbiologia; Insuficiência Renal Crônica/patologia

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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Gammaproteobacteria / Insuficiência Renal Crônica / Disbiose / Microbioma Gastrointestinal / Clostridiaceae / Metilaminas Tipo de estudo: Observational_studies / Risk_factors_studies Limite: Adult / Aged / Animals / Female / Humans / Male / Middle aged Idioma: En Ano de publicação: 2017 Tipo de documento: Article

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