Post-Myocardial Infarction T-tubules Form Enlarged Branched Structures With Dysregulation of Junctophilin-2 and Bridging Integrator 1 (BIN-1).

Pinali, Christian; Malik, Nadim; Davenport, J Bernard; Allan, Laurence J; Murfitt, Lucy; Iqbal, Mohammad M; Boyett, Mark R; Wright, Elizabeth J; Walker, Rachel; Zhang, Yu; Dobryznski, Halina; Holt, Cathy M; Kitmitto, Ashraf

Pinali, Christian; Malik, Nadim; Davenport, J Bernard; Allan, Laurence J; Murfitt, Lucy; Iqbal, Mohammad M; Boyett, Mark R; Wright, Elizabeth J; Walker, Rachel; Zhang, Yu; Dobryznski, Halina; Holt, Cathy M; Kitmitto, Ashraf.

Afiliação

Pinali C; Division of Cardiovascular Sciences, Faculty of Biology, Medicine and Health, University of Manchester, United Kingdom.
Malik N; Division of Cardiovascular Sciences, Faculty of Biology, Medicine and Health, University of Manchester, United Kingdom.
Davenport JB; Division of Cardiovascular Sciences, Faculty of Biology, Medicine and Health, University of Manchester, United Kingdom.
Allan LJ; Division of Cardiovascular Sciences, Faculty of Biology, Medicine and Health, University of Manchester, United Kingdom.
Murfitt L; Division of Cardiovascular Sciences, Faculty of Biology, Medicine and Health, University of Manchester, United Kingdom.
Iqbal MM; Division of Cardiovascular Sciences, Faculty of Biology, Medicine and Health, University of Manchester, United Kingdom.
Boyett MR; Division of Cardiovascular Sciences, Faculty of Biology, Medicine and Health, University of Manchester, United Kingdom.
Wright EJ; Division of Cardiovascular Sciences, Faculty of Biology, Medicine and Health, University of Manchester, United Kingdom.
Walker R; Division of Cardiovascular Sciences, Faculty of Biology, Medicine and Health, University of Manchester, United Kingdom.
Zhang Y; Division of Cardiovascular Sciences, Faculty of Biology, Medicine and Health, University of Manchester, United Kingdom.
Dobryznski H; Division of Cardiovascular Sciences, Faculty of Biology, Medicine and Health, University of Manchester, United Kingdom.
Holt CM; Division of Cardiovascular Sciences, Faculty of Biology, Medicine and Health, University of Manchester, United Kingdom.
Kitmitto A; Division of Cardiovascular Sciences, Faculty of Biology, Medicine and Health, University of Manchester, United Kingdom ashraf.kitmitto@manchester.ac.uk.

J Am Heart Assoc ; 6(5)2017 May 04.

Article em En | MEDLINE | ID: mdl-28473402

Assuntos

Proteínas Adaptadoras de Transdução de Sinal/metabolismo; Proteínas de Membrana/metabolismo; Infarto do Miocárdio/metabolismo; Miocárdio/metabolismo; Sarcolema/metabolismo; Função Ventricular Esquerda; Remodelação Ventricular; Animais; Modelos Animais de Doenças; Insuficiência Cardíaca/etiologia; Insuficiência Cardíaca/metabolismo; Insuficiência Cardíaca/patologia; Insuficiência Cardíaca/fisiopatologia; Contração Miocárdica; Infarto do Miocárdio/complicações; Infarto do Miocárdio/patologia; Infarto do Miocárdio/fisiopatologia; Miocárdio/ultraestrutura; Canal de Liberação de Cálcio do Receptor de Rianodina/metabolismo; Sarcolema/ultraestrutura; Sus scrofa; Disfunção Ventricular Esquerda/etiologia; Disfunção Ventricular Esquerda/metabolismo; Disfunção Ventricular Esquerda/patologia; Disfunção Ventricular Esquerda/fisiopatologia

Palavras-chave

3D electron microscopy; Eps 15 homology domain protein; bridging integrator 1 protein; heart failure; junctophilin2; myocardial infarction; transversetubules

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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Sarcolema / Função Ventricular Esquerda / Remodelação Ventricular / Proteínas Adaptadoras de Transdução de Sinal / Proteínas de Membrana / Infarto do Miocárdio / Miocárdio Tipo de estudo: Etiology_studies / Prognostic_studies Limite: Animals Idioma: En Ano de publicação: 2017 Tipo de documento: Article

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