Electric field stimulation induced neuronal differentiation of filum terminale derived neural progenitor cells.
Neurosci Lett
; 651: 109-115, 2017 06 09.
Article
em En
| MEDLINE
| ID: mdl-28476410
Adult filum terminale (FT) is an atypical region from where multipotent neural progenitor cells (NPCs) have been isolated. However, poor neuronal differentiation rate of FT-NPCs currently limits their clinical applications. Using custom-designed electric fields (EFs), this study sets up a method to significantly improve neuronal differentiation rate of rat FT-NPCs in vitro. We investigated the influence of EF strength on rat FT-NPCs differentiation. By adding reasonable strength of EF to FT-NPCs, our data shows a significant increase in neuronal differentiation rate. The present innovation provides a novel method of directional differentiation and efficient production of neurons from FT-NPCs in vitro. This improved approach for inducing neuronal differentiation can be applied to future research on autoplastic transplantation.
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MEDLINE
Assunto principal:
Cauda Equina
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Diferenciação Celular
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Estimulação Elétrica
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Células-Tronco Neurais
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Neurônios
Limite:
Animals
Idioma:
En
Ano de publicação:
2017
Tipo de documento:
Article