New ellagic acid derivative from the fruits of heat-tolerant plant Conocarpus lancifolius Engl. and their anti-inflammatory, cytotoxic, PPAR agonistic activities.
Pak J Pharm Sci
; 29(5 Suppl): 1833-1837, 2016 Sep.
Article
em En
| MEDLINE
| ID: mdl-28476711
ABSTRACT
Conocarpus lancifolius (Combretaceae), is distributed in Riyadh, Saudi Arabia. It is a heat-tolerant Saudi medicinal plant, demonstrates prominent antidiabetic potential and the fruit extract fruits showed cytotoxicity against MRC-5 cancer cell line, as well as prominent antiprotozoal and antibacterial activities. The objective of this study is to isolate the compounds and evaluate the anti-inflammatory, cytotoxic, PPAR agonistic and antioxidant activities of extracts and pure constituents from C. lancifolius. A new trimethoxyellagic acid derivative 1 and two compounds, kaempferol 3-O-rutinoside 2 and ß-sitosterol glucoside 3 were isolated from the fruits of Conocarpus lancifolius, a heat-tolerant plant. Compound 2 showed strong dual activation for PPARα and PPARγ with 2.6 fold increment in PPARα activity, while 2.2 fold increment in PPARγ at 25µ/ml. This is first report on isolation and screening of different biological activities of extract and pure constituents from fruits of C. lancifolius.
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Base de dados:
MEDLINE
Assunto principal:
Combretaceae
/
Receptores Ativados por Proliferador de Peroxissomo
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Ácido Elágico
/
Anti-Inflamatórios
/
Antineoplásicos Fitogênicos
Limite:
Humans
Idioma:
En
Ano de publicação:
2016
Tipo de documento:
Article