Cell-specific pallidal intervention induces long-lasting motor recovery in dopamine-depleted mice.
Nat Neurosci
; 20(6): 815-823, 2017 Jun.
Article
em En
| MEDLINE
| ID: mdl-28481350
ABSTRACT
The identification of distinct cell types in the basal ganglia has been critical to our understanding of basal ganglia function and the treatment of neurological disorders. The external globus pallidus (GPe) is a key contributor to motor suppressing pathways in the basal ganglia, yet its neuronal heterogeneity has remained an untapped resource for therapeutic interventions. Here we demonstrate that optogenetic interventions that dissociate the activity of two neuronal populations in the GPe, elevating the activity of parvalbumin (PV)-expressing GPe neurons over that of Lim homeobox 6 (Lhx6)-expressing GPe neurons, restores movement in dopamine-depleted mice and attenuates pathological activity of basal ganglia output neurons for hours beyond stimulation. These results establish the utility of cell-specific interventions in the GPe to target functionally distinct pathways, with the potential to induce long-lasting recovery of movement despite the continued absence of dopamine.
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Parvalbuminas
/
Fatores de Transcrição
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Dopamina
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Proteínas com Homeodomínio LIM
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Globo Pálido
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Locomoção
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Proteínas do Tecido Nervoso
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Neurônios
Tipo de estudo:
Prognostic_studies
Limite:
Animals
Idioma:
En
Ano de publicação:
2017
Tipo de documento:
Article