Uric acid priming in human monocytes is driven by the AKT-PRAS40 autophagy pathway.

Crisan, Tania O; Cleophas, Maartje C P; Novakovic, Boris; Erler, Kathrin; van de Veerdonk, Frank L; Stunnenberg, Hendrik G; Netea, Mihai G; Dinarello, Charles A; Joosten, Leo A B

Crisan, Tania O; Cleophas, Maartje C P; Novakovic, Boris; Erler, Kathrin; van de Veerdonk, Frank L; Stunnenberg, Hendrik G; Netea, Mihai G; Dinarello, Charles A; Joosten, Leo A B.

Afiliação

Crisan TO; Department of Internal Medicine, Radboud University Medical Center, 6525 GA Nijmegen, The Netherlands.
Cleophas MCP; Radboud Institute for Molecular Life Sciences, Radboud University Medical Center, 6525 GA Nijmegen, The Netherlands.
Novakovic B; Department of Medical Genetics, Iuliu Hatieganu University of Medicine and Pharmacy, 400349 Cluj-Napoca, Romania.
Erler K; Department of Internal Medicine, Radboud University Medical Center, 6525 GA Nijmegen, The Netherlands.
van de Veerdonk FL; Radboud Institute for Molecular Life Sciences, Radboud University Medical Center, 6525 GA Nijmegen, The Netherlands.
Stunnenberg HG; Radboud Institute for Molecular Life Sciences, Radboud University Medical Center, 6525 GA Nijmegen, The Netherlands.
Netea MG; Department of Molecular Biology, Faculty of Science, Radboud University, 6525 GA Nijmegen, The Netherlands.
Dinarello CA; Department of Internal Medicine, Radboud University Medical Center, 6525 GA Nijmegen, The Netherlands.
Joosten LAB; Radboud Institute for Molecular Life Sciences, Radboud University Medical Center, 6525 GA Nijmegen, The Netherlands.

Proc Natl Acad Sci U S A ; 114(21): 5485-5490, 2017 05 23.

Article em En | MEDLINE | ID: mdl-28484006

Assuntos

Proteínas Adaptadoras de Transdução de Sinal/metabolismo; Autofagia; Monócitos/metabolismo; Proteínas Proto-Oncogênicas c-akt/metabolismo; Ácido Úrico/metabolismo; Animais; Modelos Animais de Doenças; Gota/metabolismo; Doença Granulomatosa Crônica/metabolismo; Células HeLa; Humanos; Hiperuricemia/metabolismo; Proteína Antagonista do Receptor de Interleucina 1/metabolismo; Interleucina-1beta/metabolismo; Camundongos; Espécies Reativas de Oxigênio/metabolismo; Transcriptoma; Urato Oxidase/antagonistas & inibidores

Palavras-chave

AKT; autophagy; interleukin-1; interleukin-1 receptor antagonist; uric acid

Texto completo

Imprimir

XML

PubMed Links

Buscar no Google

Texto completo: 1 Base de dados: MEDLINE Assunto principal: Autofagia / Ácido Úrico / Monócitos / Proteínas Adaptadoras de Transdução de Sinal / Proteínas Proto-Oncogênicas c-akt Limite: Animals / Humans Idioma: En Ano de publicação: 2017 Tipo de documento: Article

Texto completo

Imprimir

XML

PubMed Links

Buscar no Google