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Social propinquity in rodents as measured by tube cooccupancy differs between inbred and outbred genotypes.
Tuttle, Alexander H; Tansley, Shannon; Dossett, Kimberly; Tohyama, Sarasa; Khoutorsky, Arkady; Maldonado-Bouchard, Sioui; Stein, Liane; Gerstein, Lindsey; Crawhall-Duk, Hayley; Pearl, Rebecca; Sukosd, Melissa; Leger, Philip; Hardt, Oliver M; Yachnin, David; Austin, Jean-Sebastien; Chan, Claire M; Pooters, Tine; Groves, Isabelle; Martin, Loren J; Sonenberg, Nahum; Gkogkas, Christos G; Mogil, Jeffrey S.
Afiliação
  • Tuttle AH; Department of Psychology McGill University, Montreal, QC H3A 1B1 Canada.
  • Tansley S; Alan Edwards Centre for Research on Pain, McGill University, Montreal, QC H3A 1B1 Canada.
  • Dossett K; Department of Psychology McGill University, Montreal, QC H3A 1B1 Canada.
  • Tohyama S; Alan Edwards Centre for Research on Pain, McGill University, Montreal, QC H3A 1B1 Canada.
  • Khoutorsky A; Department of Psychology McGill University, Montreal, QC H3A 1B1 Canada.
  • Maldonado-Bouchard S; Alan Edwards Centre for Research on Pain, McGill University, Montreal, QC H3A 1B1 Canada.
  • Stein L; Department of Psychology McGill University, Montreal, QC H3A 1B1 Canada.
  • Gerstein L; Alan Edwards Centre for Research on Pain, McGill University, Montreal, QC H3A 1B1 Canada.
  • Crawhall-Duk H; Department of Biochemistry McGill University, Montreal, QC H3A 1A3 Canada.
  • Pearl R; Rosalind and Morris Goodman Cancer Research Centre, McGill University, Montreal, QC H3A 1A3 Canada.
  • Sukosd M; Department of Psychology McGill University, Montreal, QC H3A 1B1 Canada.
  • Leger P; Alan Edwards Centre for Research on Pain, McGill University, Montreal, QC H3A 1B1 Canada.
  • Hardt OM; Department of Psychology McGill University, Montreal, QC H3A 1B1 Canada.
  • Yachnin D; Alan Edwards Centre for Research on Pain, McGill University, Montreal, QC H3A 1B1 Canada.
  • Austin JS; Department of Psychology McGill University, Montreal, QC H3A 1B1 Canada.
  • Chan CM; Alan Edwards Centre for Research on Pain, McGill University, Montreal, QC H3A 1B1 Canada.
  • Pooters T; Department of Psychology McGill University, Montreal, QC H3A 1B1 Canada.
  • Groves I; Alan Edwards Centre for Research on Pain, McGill University, Montreal, QC H3A 1B1 Canada.
  • Martin LJ; Department of Psychology McGill University, Montreal, QC H3A 1B1 Canada.
  • Sonenberg N; Alan Edwards Centre for Research on Pain, McGill University, Montreal, QC H3A 1B1 Canada.
  • Gkogkas CG; Department of Psychology McGill University, Montreal, QC H3A 1B1 Canada.
  • Mogil JS; Alan Edwards Centre for Research on Pain, McGill University, Montreal, QC H3A 1B1 Canada.
Proc Natl Acad Sci U S A ; 114(21): 5515-5520, 2017 05 23.
Article em En | MEDLINE | ID: mdl-28484016
ABSTRACT
Existing assays of social interaction are suboptimal, and none measures propinquity, the tendency of rodents to maintain close physical proximity. These assays are ubiquitously performed using inbred mouse strains and mutations placed on inbred genetic backgrounds. We developed the automatable tube cooccupancy test (TCOT) based on propinquity, the tendency of freely mobile rodents to maintain close physical proximity, and assessed TCOT behavior on a variety of genotypes and social and environmental conditions. In outbred mice and rats, familiarity determined willingness to cooccupy the tube, with siblings and/or cagemates of both sexes exhibiting higher cooccupancy behavior than strangers. Subsequent testing using multiple genotypes revealed that inbred strain siblings do not cooccupy at higher rates than strangers, in marked contrast to both outbred and rederived wild mice. Mutant mouse strains with "autistic-like" phenotypes (Fmr1-/y and Eif4e Ser209Ala) displayed significantly decreased cooccupancy.
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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Comportamento Social / Endogamia Limite: Animals Idioma: En Ano de publicação: 2017 Tipo de documento: Article
Texto completo
Imprimir
XML
PubMed Links
Buscar no Google

Texto completo: 1 Base de dados: MEDLINE Assunto principal: Comportamento Social / Endogamia Limite: Animals Idioma: En Ano de publicação: 2017 Tipo de documento: Article