Asymmetric Synthesis of ß-Lactams through Copper-Catalyzed Alkyne-Nitrone Coupling with a Prolinol-Phosphine Chiral Ligand.

Takayama, Yurie; Ishii, Takaoki; Ohmiya, Hirohisa; Iwai, Tomohiro; Schwarzer, Martin C; Mori, Seiji; Taniguchi, Tohru; Monde, Kenji; Sawamura, Masaya

Takayama, Yurie; Ishii, Takaoki; Ohmiya, Hirohisa; Iwai, Tomohiro; Schwarzer, Martin C; Mori, Seiji; Taniguchi, Tohru; Monde, Kenji; Sawamura, Masaya.

Afiliação

Takayama Y; Department of Chemistry, Faculty of Science, Hokkaido University, Sapporo, 060-0810, Japan.
Ishii T; Department of Chemistry, Faculty of Science, Hokkaido University, Sapporo, 060-0810, Japan.
Ohmiya H; Department of Chemistry, Faculty of Science, Hokkaido University, Sapporo, 060-0810, Japan.
Iwai T; Department of Chemistry, Faculty of Science, Hokkaido University, Sapporo, 060-0810, Japan.
Schwarzer MC; Institute of Quantum Beam Science, Ibaraki University, Mito, Ibaraki, 310-8512, Japan.
Mori S; Institute of Quantum Beam Science, Ibaraki University, Mito, Ibaraki, 310-8512, Japan.
Taniguchi T; Frontier Research Center for Advanced Material and Life Science, Faculty of Advanced Life Science, Hokkaido University, Sapporo, 060-0810, Japan.
Monde K; Frontier Research Center for Advanced Material and Life Science, Faculty of Advanced Life Science, Hokkaido University, Sapporo, 060-0810, Japan.
Sawamura M; Department of Chemistry, Faculty of Science, Hokkaido University, Sapporo, 060-0810, Japan.

Chemistry ; 23(35): 8400-8404, 2017 Jun 22.

Article em En | MEDLINE | ID: mdl-28488338

Assuntos

Alcinos/química; Cobre/química; Óxidos de Nitrogênio/química; Fosfinas/química; Pirrolidinas/química; beta-Lactamas/síntese química; Catálise; Avaliação Pré-Clínica de Medicamentos/métodos; Humanos; Ligação de Hidrogênio; Ligantes; Estereoisomerismo; Relação Estrutura-Atividade

Palavras-chave

asymmetric catalysis; cooperative catalysis; copper; nitrones; ß-lactam

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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Fosfinas / Pirrolidinas / Cobre / Beta-Lactamas / Alcinos / Óxidos de Nitrogênio Limite: Humans Idioma: En Ano de publicação: 2017 Tipo de documento: Article

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