Advantages and Some Remaining Challenges in Hereditary Gastrointestinal Cancer Panel Testing.
Clin Transl Gastroenterol
; 8(5): e92, 2017 May 11.
Article
em En
| MEDLINE
| ID: mdl-28492537
ABSTRACT
Colorectal cancer affects 1 in 20 men and women in their lifetime. About 30% of these cases have been shown to be familial while only about 5% are associated with a highly penetrant hereditary colon cancer syndrome. In many familial cases, however, no mutation in the commonly implicated CRC genes is found. With the development of next-generation sequencing, testing laboratories are now able to offer hereditary gastrointestinal panel testing, which allows for the simultaneous sequencing of a much broader set of genes associated with CRC. We discuss the advantages and disadvantages of such testing to inform best clinical practice.
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MEDLINE
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En
Ano de publicação:
2017
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Article