Functions of the DnaA protein of Escherichia coli in replication and transcription.
Biochim Biophys Acta
; 951(2-3): 351-8, 1988 Dec 20.
Article
em En
| MEDLINE
| ID: mdl-2850012
ABSTRACT
The function of DnaA protein as a replisome organizer in the initiation of DNA replication is reviewed. A model is presented showing the construction of two basic types of DnaA-dependent replication origin. New data demonstrate that the dnaA box-DnaA protein complex is a transcription terminator. Only one orientation of the dnaA box results in termination of transcription. Mutation of the dnaA box within the dnaA reading frame shows that DnaA-mediated transcription termination has a role in the autoregulation of the dnaA gene.
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Base de dados:
MEDLINE
Assunto principal:
Proteínas de Bactérias
/
Transcrição Gênica
/
Replicação do DNA
/
Escherichia coli
Tipo de estudo:
Prognostic_studies
Idioma:
En
Ano de publicação:
1988
Tipo de documento:
Article