The selective effect of glycyrrhizin and glycyrrhetinic acid on topoisomerase II&#945; and apoptosis in combination with etoposide on triple negative breast cancer MDA-MB-231 cells.

Cai, Yun; Zhao, Boxin; Liang, Qianying; Zhang, Yunqi; Cai, Jieying; Li, Guofeng

The selective effect of glycyrrhizin and glycyrrhetinic acid on topoisomerase IIα and apoptosis in combination with etoposide on triple negative breast cancer MDA-MB-231 cells.

Cai, Yun; Zhao, Boxin; Liang, Qianying; Zhang, Yunqi; Cai, Jieying; Li, Guofeng.

Afiliação

Cai Y; Department of Pharmacy, Nanfang Hospital, Southern Medical University, Guangzhou 510515, China; Rational Medication Evaluation and Drug Delivery Technology Lab, Nanfang Hospital, Southern Medical University, Guangzhou 510515, China.
Zhao B; Department of Pharmacy, Nanfang Hospital, Southern Medical University, Guangzhou 510515, China; Rational Medication Evaluation and Drug Delivery Technology Lab, Nanfang Hospital, Southern Medical University, Guangzhou 510515, China.
Liang Q; Department of Pharmacy, Nanfang Hospital, Southern Medical University, Guangzhou 510515, China; Rational Medication Evaluation and Drug Delivery Technology Lab, Nanfang Hospital, Southern Medical University, Guangzhou 510515, China.
Zhang Y; Department of Pharmacy, Nanfang Hospital, Southern Medical University, Guangzhou 510515, China; Rational Medication Evaluation and Drug Delivery Technology Lab, Nanfang Hospital, Southern Medical University, Guangzhou 510515, China.
Cai J; Department of Pharmacy, Nanfang Hospital, Southern Medical University, Guangzhou 510515, China; Rational Medication Evaluation and Drug Delivery Technology Lab, Nanfang Hospital, Southern Medical University, Guangzhou 510515, China.
Li G; Department of Pharmacy, Nanfang Hospital, Southern Medical University, Guangzhou 510515, China; Rational Medication Evaluation and Drug Delivery Technology Lab, Nanfang Hospital, Southern Medical University, Guangzhou 510515, China; Guangdong Key Laboratory of New Drug Screening, Southern Medical Un

Eur J Pharmacol ; 809: 87-97, 2017 Aug 15.

Article em En | MEDLINE | ID: mdl-28506909

Assuntos

Antineoplásicos/farmacologia; DNA Topoisomerases Tipo II/metabolismo; Etoposídeo/farmacologia; Ácido Glicirretínico/farmacologia; Ácido Glicirrízico/farmacologia; Neoplasias de Mama Triplo Negativas/patologia; Apoptose/efeitos dos fármacos; Linhagem Celular Tumoral; Proliferação de Células/efeitos dos fármacos; Sobrevivência Celular/efeitos dos fármacos; Interações Medicamentosas; Resistencia a Medicamentos Antineoplásicos/efeitos dos fármacos; Regulação Neoplásica da Expressão Gênica/efeitos dos fármacos; Humanos; Sistema de Sinalização das MAP Quinases/efeitos dos fármacos; Fosfatidilinositol 3-Quinases/metabolismo; Proteínas Proto-Oncogênicas c-akt/metabolismo

Palavras-chave

Apoptosis; Etoposide; Etoposide (PubChem CID: 36462); Glycyrrhetinic acid; Glycyrrhetinic acid (PubChem CID: 10014); Glycyrrhizin; Glycyrrhizin (PubChem CID: 14982); Topoisomerase IIα; Triple negative breast cancer

Texto completo

Imprimir

XML

PubMed Links

Buscar no Google

Texto completo: 1 Base de dados: MEDLINE Assunto principal: DNA Topoisomerases Tipo II / Ácido Glicirrízico / Etoposídeo / Neoplasias de Mama Triplo Negativas / Ácido Glicirretínico / Antineoplásicos Limite: Humans Idioma: En Ano de publicação: 2017 Tipo de documento: Article

Texto completo

Imprimir

XML

PubMed Links

Buscar no Google