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Nanoarchitecturing of Natural Melanin Nanospheres by Layer-by-Layer Assembly: Macroscale Anti-inflammatory Conductive Coatings with Optoelectronic Tunability.
Eom, Taesik; Woo, Kyungbae; Cho, Whirang; Heo, Jae Eun; Jang, Daseul; Shin, Jae In; Martin, David C; Wie, Jeong Jae; Shim, Bong Sup.
Afiliação
  • Cho W; Department of Materials Science and Engineering, University of Delaware , 201 Du Pont Hall, Newark Delaware 19716, United States.
  • Martin DC; Department of Materials Science and Engineering, University of Delaware , 201 Du Pont Hall, Newark Delaware 19716, United States.
Biomacromolecules ; 18(6): 1908-1917, 2017 Jun 12.
Article em En | MEDLINE | ID: mdl-28510430
ABSTRACT
Natural melanins are biocompatible conductors with versatile functionalities. Here, we report fabrication of multifunctional poly(vinyl alcohol)/melanin nanocomposites by layer-by-layer (LBL) assembly using melanin nanoparticles (MNPs) directly extracted from sepia officinalis inks. The LBL assembly offers facile manipulation of nanotextures as well as nm-thickness control of the macroscale film by varying solvent qualities. The time-resolved absorption was monitored during the process and quantitatively studied by fractal dimension and lacunarity analysis. The capability of nanoarchitecturing provides confirmation of complete monolayer formation and leads to tunable iridescent reflective colors of the MNP films. In addition, the MNP films have durable electrochemical conductivities as evidenced by enhanced charge storage capacities for 1000 cycles. Moreover, the MNP covered ITO (indium tin oxide) substrates significantly reduced secretion of inflammatory cytokines, TNF-α, by raw 264.7 macrophage cells compared to bare ITO, by a factor of 5 and 1.8 with and without lipopolysaccharide endotoxins, respectively. These results highlight the optoelectronic device-level tunability along with the anti-inflammatory biocompatibility of the MNP LBL film. This combination of performance should make these films particularly interesting for bioelectronic device applications such as electroceuticals, artificial bionic organs, biosensors, and implantable devices.
Assuntos

Texto completo: 1 Base de dados: MEDLINE Assunto principal: Materiais Biocompatíveis / Técnicas Biossensoriais / Nanocompostos / Nanosferas / Melaninas / Anti-Inflamatórios Limite: Animals Idioma: En Ano de publicação: 2017 Tipo de documento: Article

Texto completo: 1 Base de dados: MEDLINE Assunto principal: Materiais Biocompatíveis / Técnicas Biossensoriais / Nanocompostos / Nanosferas / Melaninas / Anti-Inflamatórios Limite: Animals Idioma: En Ano de publicação: 2017 Tipo de documento: Article