Inhibiting Translation One Protein at a Time.
Trends Biochem Sci
; 42(6): 412-413, 2017 06.
Article
em En
| MEDLINE
| ID: mdl-28522328
ABSTRACT
Historically, translational inhibitors have been confined to anti-bacterials that globally affect translation. Lintner et al. demonstrate that small molecules can specifically inhibit translation of a single disease-associated protein by stalling the ribosome's nascent chain [1], opening up a new therapeutic strategy for 'undruggable' proteins.
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Biossíntese de Proteínas
/
Inibidores de Serina Proteinase
/
Inibidores de PCSK9
/
Compostos Heterocíclicos de 4 ou mais Anéis
Limite:
Humans
Idioma:
En
Ano de publicação:
2017
Tipo de documento:
Article