Obestatin controls skeletal muscle fiber-type determination.
Sci Rep
; 7(1): 2137, 2017 05 18.
Article
em En
| MEDLINE
| ID: mdl-28522824
ABSTRACT
Obestatin/GPR39 signaling stimulates skeletal muscle growth and repair by inducing both G-protein-dependent and -independent mechanisms linking the activated GPR39 receptor with distinct sets of accessory and effector proteins. In this work, we describe a new level of activity where obestatin signaling plays a role in the formation, contractile properties and metabolic profile of skeletal muscle through determination of oxidative fiber type. Our data indicate that obestatin regulates Mef2 activity and PGC-1α expression. Both mechanisms result in a shift in muscle metabolism and function. The increase in Mef2 and PGC-1α signaling activates oxidative capacity, whereas Akt/mTOR signaling positively regulates myofiber growth. Taken together, these data indicate that the obestatin signaling acts on muscle fiber-type program in skeletal muscle.
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Fibras Musculares Esqueléticas
/
Desenvolvimento Muscular
/
Grelina
Limite:
Animals
Idioma:
En
Ano de publicação:
2017
Tipo de documento:
Article