What Do Structures Tell Us About Chemokine Receptor Function and Antagonism?

Kufareva, Irina; Gustavsson, Martin; Zheng, Yi; Stephens, Bryan S; Handel, Tracy M

Kufareva, Irina; Gustavsson, Martin; Zheng, Yi; Stephens, Bryan S; Handel, Tracy M.

Afiliação

Kufareva I; Skaggs School of Pharmacy and Pharmaceutical Sciences, University of California, San Diego, La Jolla, California 92093; email: ikufareva@ucsd.edu , thandel@ucsd.edu.
Gustavsson M; Skaggs School of Pharmacy and Pharmaceutical Sciences, University of California, San Diego, La Jolla, California 92093; email: ikufareva@ucsd.edu , thandel@ucsd.edu.
Zheng Y; Skaggs School of Pharmacy and Pharmaceutical Sciences, University of California, San Diego, La Jolla, California 92093; email: ikufareva@ucsd.edu , thandel@ucsd.edu.
Stephens BS; Skaggs School of Pharmacy and Pharmaceutical Sciences, University of California, San Diego, La Jolla, California 92093; email: ikufareva@ucsd.edu , thandel@ucsd.edu.
Handel TM; Skaggs School of Pharmacy and Pharmaceutical Sciences, University of California, San Diego, La Jolla, California 92093; email: ikufareva@ucsd.edu , thandel@ucsd.edu.

Annu Rev Biophys ; 46: 175-198, 2017 05 22.

Article em En | MEDLINE | ID: mdl-28532213

Assuntos

Receptores de Quimiocinas/antagonistas & inibidores; Receptores de Quimiocinas/química; Regulação Alostérica; Animais; Quimiocinas/química; Quimiocinas/metabolismo; Cristalografia por Raios X; Descoberta de Drogas; Humanos; Modelos Moleculares

Palavras-chave

G proteincoupled receptor; allostery; crystallography; druggability; molecular modeling; receptor activation

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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Receptores de Quimiocinas Limite: Animals / Humans Idioma: En Ano de publicação: 2017 Tipo de documento: Article

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