Xanthine oxidase inhibition protects against Western diet-induced aortic stiffness and impaired vasorelaxation in female mice.

Lastra, Guido; Manrique, Camila; Jia, Guanghong; Aroor, Annayya R; Hayden, Melvin R; Barron, Brady J; Niles, Brett; Padilla, Jaume; Sowers, James R

Lastra, Guido; Manrique, Camila; Jia, Guanghong; Aroor, Annayya R; Hayden, Melvin R; Barron, Brady J; Niles, Brett; Padilla, Jaume; Sowers, James R.

Afiliação

Lastra G; Department of Medicine, Division of Endocrinology, University of Missouri, Columbia, Missouri; lastrag@health.missouri.edu.
Manrique C; Department of Medicine, Division of Endocrinology, University of Missouri, Columbia, Missouri.
Jia G; University of Missouri, School of Medicine, Research Service Harry S. Truman Memorial Veterans Hospital, University of Missouri, Columbia, Missouri.
Aroor AR; Department of Medicine, Division of Endocrinology, University of Missouri, Columbia, Missouri.
Hayden MR; Department of Medicine, Division of Endocrinology, University of Missouri, Columbia, Missouri.
Barron BJ; University of Missouri, School of Medicine, Research Service Harry S. Truman Memorial Veterans Hospital, University of Missouri, Columbia, Missouri.
Niles B; Department of Medicine, Division of Endocrinology, University of Missouri, Columbia, Missouri.
Padilla J; Department of Medicine, Division of Endocrinology, University of Missouri, Columbia, Missouri.
Sowers JR; University of Missouri, School of Medicine, Research Service Harry S. Truman Memorial Veterans Hospital, University of Missouri, Columbia, Missouri.

Am J Physiol Regul Integr Comp Physiol ; 313(2): R67-R77, 2017 Aug 01.

Article em En | MEDLINE | ID: mdl-28539355

Assuntos

Alopurinol/administração & dosagem; Aorta/fisiologia; Dieta Ocidental; Ácido Úrico/sangue; Rigidez Vascular/fisiologia; Vasodilatação/fisiologia; Xantina Oxidase/metabolismo; Animais; Aorta/efeitos dos fármacos; Inibidores Enzimáticos/administração & dosagem; Feminino; Camundongos; Camundongos Endogâmicos C57BL; Estresse Oxidativo/efeitos dos fármacos; Estresse Oxidativo/fisiologia; Rigidez Vascular/efeitos dos fármacos; Vasodilatação/efeitos dos fármacos; Sistema Vasomotor/efeitos dos fármacos; Sistema Vasomotor/fisiologia; Xantina Oxidase/antagonistas & inibidores

Palavras-chave

Western diet; allopurinol; females; oxidative stress; vascular stiffness

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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Aorta / Ácido Úrico / Vasodilatação / Xantina Oxidase / Alopurinol / Rigidez Vascular / Dieta Ocidental Tipo de estudo: Prognostic_studies Limite: Animals Idioma: En Ano de publicação: 2017 Tipo de documento: Article

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