Global epidemiology of CTX-M ß-lactamases: temporal and geographical shifts in genotype.
J Antimicrob Chemother
; 72(8): 2145-2155, 2017 08 01.
Article
em En
| MEDLINE
| ID: mdl-28541467
ABSTRACT
Globally, rates of ESBL-producing Enterobacteriaceae are rising. We undertook a literature review, and present the temporal trends in blaCTX-M epidemiology, showing that blaCTX-M-15 and blaCTX-M-14 have displaced other genotypes in many parts of the world. Explanations for these changes can be attributed to (i) horizontal gene transfer (HGT) of plasmids; (ii) successful Escherichia coli clones; (iii) ESBLs in food animals; (iv) the natural environment; and (v) human migration and access to basic sanitation. We also provide explanations for the changing epidemiology of blaCTX-M-2 and blaCTX-M-27. Modifiable anthropogenic factors, such as poor access to basic sanitary facilities, encourage the spread of blaCTX-M and other antimicrobial resistance (AMR) genes, such as blaNDM, blaKPC and mcr-1. We provide further justification for novel preventative and interventional strategies to reduce transmission of these AMR genes.
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Beta-Lactamases
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Enterobacteriaceae
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Infecções por Enterobacteriaceae
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Genótipo
Tipo de estudo:
Screening_studies
Limite:
Animals
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Humans
Idioma:
En
Ano de publicação:
2017
Tipo de documento:
Article