Integrity of immunoglobulin variable regions is supported by GANP during AID-induced somatic hypermutation in germinal center B cells.

Eid, Mohammed Mansour Abbas; Shimoda, Mayuko; Singh, Shailendra Kumar; Almofty, Sarah Ameen; Pham, Phuong; Goodman, Myron F; Maeda, Kazuhiko; Sakaguchi, Nobuo

Eid, Mohammed Mansour Abbas; Shimoda, Mayuko; Singh, Shailendra Kumar; Almofty, Sarah Ameen; Pham, Phuong; Goodman, Myron F; Maeda, Kazuhiko; Sakaguchi, Nobuo.

Afiliação

Eid MMA; Clinical Pathology Department, Faculty of Medicine, Fayoum University, PO Box 63514, Fayoum, Egypt.
Shimoda M; Department of Immunology, Graduate School of Medical Sciences, Kumamoto University, 1-1-1 Honjo, Kumamoto 860-8556, Japan.
Singh SK; Laboratory of Host Defense, World Premier International Research Center Initiative (WPI) Immunology Frontier Research Center (IFReC).
Almofty SA; Department of Host Defense, Research Institute for Microbial Diseases (RIMD), Osaka University, 3-1 Yamada-oka, Suita, Osaka 565-0871, Japan.
Pham P; Laboratory of Host Defense, World Premier International Research Center Initiative (WPI) Immunology Frontier Research Center (IFReC).
Goodman MF; Laboratory of Immunology, Institute for Research and Medical Consultations (IRMC), University Of Dammam (UOD), PO Box 1982, Dammam 31441, Saudi Arabia.
Maeda K; Departments of Biological Sciences and Chemistry, University of Southern California, 1050 Childs Way, University Park, Los Angeles, CA 90089-2910, USA.
Sakaguchi N; Departments of Biological Sciences and Chemistry, University of Southern California, 1050 Childs Way, University Park, Los Angeles, CA 90089-2910, USA.

Int Immunol ; 29(5): 211-220, 2017 05 01.

Article em En | MEDLINE | ID: mdl-28541550

Assuntos

Linfócitos B/imunologia; Centro Germinativo/imunologia; Região Variável de Imunoglobulina/genética; Mutação/genética; Proteínas Nucleares/genética; Fosfoproteínas/genética; Animais; Afinidade de Anticorpos; Teorema de Bayes; Células Cultivadas; Citidina Desaminase/metabolismo; Reparo do DNA; Região Variável de Imunoglobulina/metabolismo; Camundongos; Camundongos Knockout; Proteínas Nucleares/metabolismo; Fosfoproteínas/metabolismo; Conformação Proteica; Hipermutação Somática de Imunoglobulina

Palavras-chave

DNA repair pathways; SHM; activation-induced cytidine deaminase; affinity maturation; antibody

Texto completo

Imprimir

XML

PubMed Links

Buscar no Google

Texto completo: 1 Base de dados: MEDLINE Assunto principal: Fosfoproteínas / Região Variável de Imunoglobulina / Proteínas Nucleares / Linfócitos B / Centro Germinativo / Mutação Tipo de estudo: Prognostic_studies Limite: Animals Idioma: En Ano de publicação: 2017 Tipo de documento: Article

Texto completo

Imprimir

XML

PubMed Links

Buscar no Google