DNA damage marker phosphorylated histone H2AX is a potential predictive marker for progression of epithelial dysplasia of the oral cavity.

Leung, Elaine Y; McMahon, Jeremy D; McLellan, Douglas R; Syyed, Nazlie; McCarthy, Caroline E; Nixon, Colin; Orange, Clare; Brock, Claire; Hunter, Keith D; Adams, Peter D

Leung, Elaine Y; McMahon, Jeremy D; McLellan, Douglas R; Syyed, Nazlie; McCarthy, Caroline E; Nixon, Colin; Orange, Clare; Brock, Claire; Hunter, Keith D; Adams, Peter D.

Afiliação

Leung EY; Wolfson Wohl Cancer Research Centre, Institute of Cancer Sciences, University of Glasgow, Glasgow, UK.
McMahon JD; Queen Elizabeth University Hospital, Glasgow, UK.
McLellan DR; Queen Elizabeth University Hospital, Glasgow, UK.
Syyed N; Queen Elizabeth University Hospital, Glasgow, UK.
McCarthy CE; Academic Unit of Oral and Maxillofacial Pathology, The University of Sheffield, Sheffield, UK.
Nixon C; Cancer Research UK Beatson Institute, Glasgow, UK.
Orange C; Queen Elizabeth University Hospital, Glasgow, UK.
Brock C; Cancer Research UK Beatson Institute, Glasgow, UK.
Hunter KD; Academic Unit of Oral and Maxillofacial Pathology, The University of Sheffield, Sheffield, UK.
Adams PD; Cancer Research UK Beatson Institute, Glasgow, UK.

Histopathology ; 71(4): 522-528, 2017 Oct.

Article em En | MEDLINE | ID: mdl-28543539

Assuntos

Biomarcadores Tumorais/metabolismo; Carcinoma de Células Escamosas/metabolismo; Histonas/metabolismo; Neoplasias Bucais/metabolismo; Idoso; Biomarcadores Tumorais/genética; Carcinoma de Células Escamosas/patologia; Senescência Celular; Estudos de Coortes; Dano ao DNA; Progressão da Doença; Epitélio/metabolismo; Epitélio/patologia; Histonas/genética; Humanos; Imuno-Histoquímica; Pessoa de Meia-Idade; Boca/metabolismo; Boca/patologia; Neoplasias Bucais/patologia; Fosforilação; Valor Preditivo dos Testes; Estudos Retrospectivos

Palavras-chave

biomarkers; carcinoma in situ; cellular senescence; immunohistochemistry; neoplasm; oral cavity

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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Neoplasias Bucais / Histonas / Carcinoma de Células Escamosas / Biomarcadores Tumorais Tipo de estudo: Etiology_studies / Incidence_studies / Observational_studies / Prognostic_studies / Risk_factors_studies Limite: Aged / Humans / Middle aged Idioma: En Ano de publicação: 2017 Tipo de documento: Article

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